SEMATILIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H23N3O3S
Molecular Weight	313.416
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)CCNC(=O)C1=CC=C(NS(C)(=O)=O)C=C1

InChI

InChIKey=KHYPYQZQJSBPIX-UHFFFAOYSA-N

InChI=1S/C14H23N3O3S/c1-4-17(5-2)11-10-15-14(18)12-6-8-13(9-7-12)16-21(3,19)20/h6-9,16H,4-5,10-11H2,1-3H3,(H,15,18)

HIDE SMILES / InChI

Molecular Formula	C14H23N3O3S
Molecular Weight	313.416
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7563974 | https://www.ncbi.nlm.nih.gov/pubmed/9184799 | https://adisinsight.springer.com/drugs/800000194

Sematilide (CK-1752) was developed as a novel class III antiarrhythmic agent for the arrhythmia treatment. Sematilide blocks the inward rectifier potassium channel (IK1). The further development of the drug was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Synthesis and cardiac electrophysiological activity of aryl-substituted derivatives of the class III antiarrhythmic agent sematilide. Potential class I/III agents.	1990 Feb	2299628
Effects of a typical I(Kr) channel blocker sematilide on the relationship between ventricular repolarization, refractoriness and onset of torsades de pointes.	2002 Apr	12046984
Lesion evidence that two distinct regions within prefrontal cortex are critical for n-back performance in humans.	2009 Dec	19199405

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:36:47 GMT 2023` Edited by `admin` on `Fri Dec 15 18:36:47 GMT 2023`
Record UNII	0NHB13IN3R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SEMATILIDE

Official Name

English

Sematilide [WHO-DD]

Common Name

English

BENZAMIDE, N-(2-(DIETHYLAMINO)ETHYL)-4-((METHYLSULFONYL)AMINO)-

Systematic Name

English

sematilide [INN]

Common Name

English

SEMATILIDE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47793