DOXENITOIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H14N2O
Molecular Weight	238.2845
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C1NCNC1(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=FEJIIZAOQRTGPC-UHFFFAOYSA-N

InChI=1S/C15H14N2O/c18-14-15(17-11-16-14,12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,17H,11H2,(H,16,18)

HIDE SMILES / InChI

Molecular Formula	C15H14N2O
Molecular Weight	238.2845
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugfuture.com/chemdata/doxenitoin.html | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 451, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ | Frey, H.-H., Janz, D. (2012) Antiepileptic Drugs, page 357, retrieved from: https://books.google.ru/books?id=KW7pCAAAQBAJ

Doxenitoin is a phenytoin-like structure, the only difference being reduction of the carbonyl at the 2-position to a methylene group. This drug has significant anticonvulsant potency. It was developed as an antiepileptic agent.

Approval Year

PubMed

Title	Date	PubMed
[Experimentation with a new antiepileptic drug derived from phenytoin: 5,5-diphenyltetrahydroimidazole-4-one (glior)].	1959	13803201
[Biochemical aspects of the potentiation of pentobarbital and Glior by SKF 525-A].	1966	5973816

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:10:49 GMT 2023` Edited by `admin` on `Fri Dec 15 15:10:49 GMT 2023`
Record UNII	0K2ALD8B7K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DOXENITOIN

Official Name

English

SKF-2599

Code

English

SKF 2599

Code

English

DOXENITOIN [MI]

Common Name

English

5,5-DIPHENYL-4-IMIDAZOLIDINONE

Systematic Name

English

doxenitoin [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C264