Polzastobart

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 10:05:30 GMT 2025` Edited by `admin` on `Wed Apr 02 10:05:30 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Type	COMPLETE
Record UNII	0ENU8YY1SS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Polzastobart

Official Name

English

Immunoglobulin G4 [231-proline], anti-(human leukocyte Ig-like receptor LILRB2) (human-Rattus norvegicus monoclonal JTX-8064 ?4-chain), disulfide with human-Rattus norvegicus monoclonal JTX-8064 ?-chain, dimer

Preferred Name

English

immunoglobulin G4-kappa, anti-[Homo sapiens LILRB2 (leukocyte immunoglobulin like receptor B2, ILT4, LIR-2, MIR10, CD85d)], humanized monoclonal antibody; gamma4 heavy chain humanized (1-450) [VH humanized (Homo sapiens IGHV2-5*01 (86,9%) -(IGHD) -IGHJ1*

Common Name

English

POLZASTOBART [USAN]

Common Name

English

polzastobart [INN]

Common Name

English

JTX 8064 [WHO-DD]

Common Name

English

JTX-8064

Common Name

English

Code System Code Type Description

INN

12249

Created by admin on Wed Apr 02 10:05:30 GMT 2025 , Edited by admin on Wed Apr 02 10:05:30 GMT 2025

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NCI_THESAURUS

C178281

Created by admin on Wed Apr 02 10:05:30 GMT 2025 , Edited by admin on Wed Apr 02 10:05:30 GMT 2025

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SMS_ID

300000046883

Created by admin on Wed Apr 02 10:05:30 GMT 2025 , Edited by admin on Wed Apr 02 10:05:30 GMT 2025

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CAS

2640981-19-5

Created by admin on Wed Apr 02 10:05:30 GMT 2025 , Edited by admin on Wed Apr 02 10:05:30 GMT 2025

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USAN

LM-141

Created by admin on Wed Apr 02 10:05:30 GMT 2025 , Edited by admin on Wed Apr 02 10:05:30 GMT 2025

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FDA UNII

0ENU8YY1SS

Created by admin on Wed Apr 02 10:05:30 GMT 2025 , Edited by admin on Wed Apr 02 10:05:30 GMT 2025

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From	To
4_134	4_194
4_23	4_88
3_134	3_194
3_23	3_88
2_370	2_428
2_264	2_324
2_150	2_206
2_137	4_214
2_22	2_97
1_370	1_428
1_264	1_324
1_232	2_232
1_229	2_229
1_150	1_206
1_137	3_214
1_22	1_97

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					FHZ2SJR447

LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY B MEMBER 2

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					0ENU8YY1SS

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_450] [2_450]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS		Amount:	PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL
The complementarity-determining regions (CDRs)	PROTEIN FEATURE
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL