NEDOCROMIL

US Previously Marketed

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H17NO7
Molecular Weight	371.3408
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCC1=C2OC(=CC(=O)C2=CC3=C1N(CC)C(=CC3=O)C(O)=O)C(O)=O

InChI

InChIKey=RQTOOFIXOKYGAN-UHFFFAOYSA-N

InChI=1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26)

HIDE SMILES / InChI

Molecular Formula	C19H17NO7
Molecular Weight	371.3408
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021009s010lbl.pdf
Curator's Comment: description was created based on several sources, including https://www.drugbank.ca/drugs/DB00716 | https://www.drugs.com/ppa/nedocromil-sodium.html | http://reference.medscape.com/drug/alocril-nedocromil-ophthalmic-999594

Nedocromil is a medication considered as mast cell stabilizer used to treat itching associated with allergic conjunctivitis. Nedocromil has been shown to inhibit the in vitro activation of, and mediator release from, a variety of inflammatory cell types associated with asthma, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets. Nedocromil inhibits activation and release of inflammatory mediators such as histamine, prostaglandin D2 and leukotrienes c4 from different types of cells in the lumen and mucosa of the bronchial tree. These mediators are derived from arachidonic acid metabolism through the lipoxygenase and cyclo-oxygenase pathways. The mechanism of action of nedocromil may be due partly to inhibition of axon reflexes and release of sensory neuropeptides, such as substance P, neurokinin A, and calcitonin-geneñrelated peptides. The result is inhibition of bradykinin-induced bronchoconstriction. Nedocromil does not possess any bronchodilator, antihistamine, or corticosteroid activity. Nedocromil is indicated for the treatment of itching associated with allergic conjunctivitis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
eosinophil chemotaxis 6 Target ID: GO:0048245 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9150324	Inhibitor 8297
mast cell degranulation 7 Target ID: GO:0043303 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26803520	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Itching associated with allergic conjunctivitis 5 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021009s010lbl.pdf	Primary		Approved 8429	TILADE Approved Use ALOCRIL ® ophthalmic solution is indicated for the treatment of itching associated with allergic conjunctivitis. Launch Date 7.2567357E11
Asthma 241 Sources: https://www.drugs.com/ppa/nedocromil-sodium.html	Primary		Approved 8429	TILADE Approved Use ALOCRIL ® ophthalmic solution is indicated for the treatment of itching associated with allergic conjunctivitis. Launch Date 7.2567357E11

C_max

Value	Dose	Analyte	Population
13.7 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2825746/	6 μg/kg bw single, intravenous dose: 6 μg/kg bw route of administration: Intravenous experiment type: SINGLE co-administered:	NEDOCROMIL plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
2.1 ng/mL OTHER GOV https://www.accessdata.fda.gov/drugsatfda_docs/nda/97/020750ap_Tilade_clinphrmr.pdf	4 mg single, respiratory dose: 4 mg route of administration: Respiratory experiment type: SINGLE co-administered:	NEDOCROMIL plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
5.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2825746/	70.5 mg single, oral dose: 70.5 mg route of administration: Oral experiment type: SINGLE co-administered:	NEDOCROMIL plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
2.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2825746/	4 mg single, respiratory dose: 4 mg route of administration: Respiratory experiment type: SINGLE co-administered:	NEDOCROMIL plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
2.6 ng/mL OTHER GOV https://www.accessdata.fda.gov/drugsatfda_docs/nda/97/020750ap_Tilade_clinphrmr.pdf	20 mg single, respiratory dose: 20 mg route of administration: Respiratory experiment type: SINGLE co-administered:	NEDOCROMIL plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
3.3 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2825746/	4 mg single, respiratory dose: 4 mg route of administration: Respiratory experiment type: SINGLE co-administered:	NEDOCROMIL plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
13.4 ng/mL OTHER GOV https://www.accessdata.fda.gov/drugsatfda_docs/nda/97/020750ap_Tilade_clinphrmr.pdf	0.42 mg single, intravenous dose: 0.42 mg route of administration: Intravenous experiment type: SINGLE co-administered:	NEDOCROMIL plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

AUC

Value	Dose	Analyte	Population
10.4 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2825746/	6 μg/kg bw single, intravenous dose: 6 μg/kg bw route of administration: Intravenous experiment type: SINGLE co-administered:	NEDOCROMIL plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
4.6 ng × h/mL OTHER GOV https://www.accessdata.fda.gov/drugsatfda_docs/nda/97/020750ap_Tilade_clinphrmr.pdf	4 mg single, respiratory dose: 4 mg route of administration: Respiratory experiment type: SINGLE co-administered:	NEDOCROMIL plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
49.1 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2825746/	70.5 mg single, oral dose: 70.5 mg route of administration: Oral experiment type: SINGLE co-administered:	NEDOCROMIL plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
5.6 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2825746/	4 mg single, respiratory dose: 4 mg route of administration: Respiratory experiment type: SINGLE co-administered:	NEDOCROMIL plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
6.2 ng × h/mL OTHER GOV https://www.accessdata.fda.gov/drugsatfda_docs/nda/97/020750ap_Tilade_clinphrmr.pdf	20 mg single, respiratory dose: 20 mg route of administration: Respiratory experiment type: SINGLE co-administered:	NEDOCROMIL plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
9.4 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2825746/	4 mg single, respiratory dose: 4 mg route of administration: Respiratory experiment type: SINGLE co-administered:	NEDOCROMIL plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
8.9 ng × h/mL OTHER GOV https://www.accessdata.fda.gov/drugsatfda_docs/nda/97/020750ap_Tilade_clinphrmr.pdf	0.42 mg single, intravenous dose: 0.42 mg route of administration: Intravenous experiment type: SINGLE co-administered:	NEDOCROMIL plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

T_1/2

Value	Dose	Analyte	Population
21.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2825746/	70.5 mg single, oral dose: 70.5 mg route of administration: Oral experiment type: SINGLE co-administered:	NEDOCROMIL plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
1.5 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2825746/	4 mg single, respiratory dose: 4 mg route of administration: Respiratory experiment type: SINGLE co-administered:	NEDOCROMIL plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
2.3 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2825746/	4 mg single, respiratory dose: 4 mg route of administration: Respiratory experiment type: SINGLE co-administered:	NEDOCROMIL plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
31.6 h OTHER GOV https://www.accessdata.fda.gov/drugsatfda_docs/nda/97/020750ap_Tilade_clinphrmr.pdf	0.42 mg single, intravenous dose: 0.42 mg route of administration: Intravenous experiment type: SINGLE co-administered:	NEDOCROMIL plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
2 % 2 times / day multiple, ophthalmic Highest studied dose Dose: 2 %, 2 times / day Route: ophthalmic Route: multiple Dose: 2 %, 2 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/1999/21009lbl.pdf Page: CR 1957	unhealthy, 12-61 n = 289 Health Status: unhealthy Condition: allergic conjunctivitis Age Group: 12-61 Sex: M+F Population Size: 289 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/1999/21009lbl.pdf Page: CR 1957	Disc. AE: Eyeball itching, Swelling... AEs leading to discontinuation/dose reduction: Eyeball itching Swelling Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/1999/21009lbl.pdf Page: CR 1957

AEs

AE	Significance	Dose	Population
Eyeball itching	Disc. AE	2 % 2 times / day multiple, ophthalmic Highest studied dose Dose: 2 %, 2 times / day Route: ophthalmic Route: multiple Dose: 2 %, 2 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/1999/21009lbl.pdf Page: CR 1957	unhealthy, 12-61 n = 289 Health Status: unhealthy Condition: allergic conjunctivitis Age Group: 12-61 Sex: M+F Population Size: 289 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/1999/21009lbl.pdf Page: CR 1957
Swelling	Disc. AE	2 % 2 times / day multiple, ophthalmic Highest studied dose Dose: 2 %, 2 times / day Route: ophthalmic Route: multiple Dose: 2 %, 2 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/1999/21009lbl.pdf Page: CR 1957	unhealthy, 12-61 n = 289 Health Status: unhealthy Condition: allergic conjunctivitis Age Group: 12-61 Sex: M+F Population Size: 289 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/1999/21009lbl.pdf Page: CR 1957

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
	CYP 270 UGT 192

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
CYP 270	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021009s010lbl.pdf#page=1 Page: 1.0	no
UGT 192	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021009s010lbl.pdf#page=1 Page: 1.0	no

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:7492	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:7492
ChemicalBook	CB9122310	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB9122310
MolPort	MolPort-006-167-614	https://www.molport.com/shop/molecule-link/MolPort-006-167-614
ZINC	ZINC000003782807	http://zinc15.docking.org/substances/ZINC000003782807

PubMed

Title	Date	PubMed
Inhaled hyperosmolar agents for bronchiectasis.	2001	11406058
Bronchial, alveolar, and vascular-induced anaphylaxis and irritant-induced cardiovascular and pulmonary responses.	2001 Aug	11544156
Double-blind, randomized, placebo-controlled trial of effect of nedocromil sodium on clinical and inflammatory parameters of asthma in children allergic to dust mite.	2001 Jun	11421896
Exhaled nitric oxide in seasonal allergic rhinitis: influence of pollen season and therapy.	2001 Mar	11260152
Dehydration behavior of nedocromil magnesium pentahydrate.	2001 Mar 14	11250110
Nedocromil sodium and levocabastine reduce the symptoms of conjunctival allergen challenge by different mechanisms.	2001 Sep	11544467
Water aerosols and cough.	2002	12099765
Montelukast: a review of its therapeutic potential in asthma in children 2 to 14 years of age.	2002	11888359
Twice-daily and once-daily nedocromil sodium 2% ophthalmic solution for the treatment of seasonal allergic conjunctivitis.	2002 Jan-Feb	12008862
Review: nedocromil sodium decreases airflow reduction and recovery time in exercise-induced bronchoconstriction.	2002 Sep-Oct	12207449
Antiasthmatic effects of nedocromil sodium.	2003	15168867
Single-dose agents in the prevention of exercise-induced asthma: a descriptive review.	2004	15658883
Long-term effect of budesonide on hypothalamic-pituitary-adrenal axis function in children with mild to moderate asthma.	2004 Jun	15173493
Investigation into the mechanisms by which nedocromil sodium, frusemide and bumetanide inhibit the histamine-induced itch and flare response in human skin in vivo.	2004 Mar	15005740
The management of asthma and rhinitis during pregnancy.	2005 Apr	15857273
Respiratory morbidity in office workers in a water-damaged building.	2005 Apr	15811840
Asthma controller therapy during pregnancy.	2005 Feb	15695974

Patents

Sample Use Guides

In Vivo Use Guide

Instill 1-2 gtt in each eye twice daily throughout time of exposure (ie, until pollen season is over or offending allergen terminated)

Route of Administration: Topical

In Vitro Use Guide

Eosinophil chemotaxis was studied using a modified Boyden chamber technique. Sets of six chambers each were set up to investigate different experimental conditions. Half a millilitre of either medium 199, conditioned medium, or conditioned medium containing 10^-7, 10^-6 or 10^-5 M nedocromil sodium, was placed in the lower compartment of each chamber, and incubated for 90 min at 37°C in the presence of 2510^3 eosinophils in the upper compartment, separated by an 8 m pore size microporous polycarbonate membrane. At the end of incubation, the membrane was removed, fixed in absolute alcohol for 5 min and then washed under running tap water for 1 min. The membrane was stained with Chromotrope R for 5 min. The stained membrane was dehydrated in absolute alcohol for 5 min, cleared in CNP 30 reagent (BDH LaboratorySupplies, Lutterworth, UK), and then mounted in Styrolite™ mounting medium. The membrane was immediately examined by light microscopy, and the number of eosinophils coming through to the other side of the membrane was counted in 10 random high power fields (HPF) at x40 magnification.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:46:24 UTC 2023` Edited by `admin` on `Fri Dec 15 15:46:24 UTC 2023`
Record UNII	0B535E0BN0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NEDOCROMIL

Official Name

English

nedocromil [INN]

Common Name

English

FPL 59002

Code

English

FPL-59002

Code

English

9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid

Systematic Name

English

NEDOCROMIL [USAN]

Common Name

English

Nedocromil [WHO-DD]

Common Name

English

NEDOCROMIL [MI]

Common Name

English

NEDOCROMIL [VANDF]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578