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Details

Stereochemistry ACHIRAL
Molecular Formula C17H18FN3O2S
Molecular Weight 347.407
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of WAY-208466

SMILES

CN(C)CCN1C=C(C2=CC=CN=C12)S(=O)(=O)C3=CC(F)=CC=C3

InChI

InChIKey=SFSFIDVAEMDPIP-UHFFFAOYSA-N
InChI=1S/C17H18FN3O2S/c1-20(2)9-10-21-12-16(15-7-4-8-19-17(15)21)24(22,23)14-6-3-5-13(18)11-14/h3-8,11-12H,9-10H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C17H18FN3O2S
Molecular Weight 347.407
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

WAY 208466 dihydrochloride is a high affinity, selective SR-6 (5-HT6) receptor agonist. WAY-208466 produced both antidepressant-like and anxiolytic-like effects. Direct infusion of WAY-208466 into the dorsal raphe nucleus, locus coeruleus, basal forebrain (horizontal limb of the diagonal band of Broca) or laterodorsal tegmental nucleus specifically decreased REM sleep without significantly altering wakefulness or slow wave sleep.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
4.8 nM [Ki]
217.0 nM [Ki]
644.0 nM [Ki]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown
Primary
Unknown

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
Rat: 10 mg/kg once a day
Route of Administration: Other
In Vitro Use Guide
In the presence of DL-TBOA, WAY208466 (30 uM) effectively caused an average inhibition of 35 % of 4-aminopyridine-evoked glutamate release; the inhibition was similar to that produced by WAY208466 alone (41%).
Substance Class Chemical
Record UNII
0AXW9ALG9W
Record Status Validated (UNII)
Record Version