Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C17H18FN3O2S.2ClH |
| Molecular Weight | 420.329 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.CN(C)CCN1C=C(C2=C1N=CC=C2)S(=O)(=O)C3=CC(F)=CC=C3
InChI
InChIKey=BAOHMLBVCLITHA-UHFFFAOYSA-N
InChI=1S/C17H18FN3O2S.2ClH/c1-20(2)9-10-21-12-16(15-7-4-8-19-17(15)21)24(22,23)14-6-3-5-13(18)11-14;;/h3-8,11-12H,9-10H2,1-2H3;2*1H
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C17H18FN3O2S |
| Molecular Weight | 347.407 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/20217056 | https://www.ncbi.nlm.nih.gov/pubmed/23624323
Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/20217056 | https://www.ncbi.nlm.nih.gov/pubmed/23624323
WAY 208466 dihydrochloride is a high affinity, selective SR-6 (5-HT6) receptor agonist. WAY-208466 produced both antidepressant-like and anxiolytic-like effects. Direct infusion of WAY-208466 into the dorsal raphe nucleus, locus coeruleus, basal forebrain (horizontal limb of the diagonal band of Broca) or laterodorsal tegmental nucleus specifically decreased REM sleep without significantly altering wakefulness or slow wave sleep.
CNS Activity
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| WAY208466 inhibits glutamate release at hippocampal nerve terminals. | 2016-06-15 |
|
| Serotonin₆ receptors in the dorsal hippocampus regulate depressive-like behaviors in unilateral 6-hydroxydopamine-lesioned Parkinson's rats. | 2015-08 |
|
| The effects of systemic and local microinjection into the central nervous system of the selective serotonin 5-HT6 receptor agonist WAY-208466 on sleep and wakefulness in the rat. | 2013-07-15 |
|
| Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats. | 2011-02 |
|
| Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. | 2008-05 |
Patents
Sample Use Guides
| Substance Class |
Chemical
Created
by
admin
on
Edited
Tue Apr 01 16:33:49 GMT 2025
by
admin
on
Tue Apr 01 16:33:49 GMT 2025
|
| Record UNII |
8ID7Y1EE12
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Preferred Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
1207064-61-6
Created by
admin on Tue Apr 01 16:33:49 GMT 2025 , Edited by admin on Tue Apr 01 16:33:49 GMT 2025
|
PRIMARY | |||
|
8ID7Y1EE12
Created by
admin on Tue Apr 01 16:33:49 GMT 2025 , Edited by admin on Tue Apr 01 16:33:49 GMT 2025
|
PRIMARY | |||
|
22028182
Created by
admin on Tue Apr 01 16:33:49 GMT 2025 , Edited by admin on Tue Apr 01 16:33:49 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |