Stereochemistry | ACHIRAL |
Molecular Formula | C19H17NOS |
Molecular Weight | 307.409 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C(=S)OC1=CC=C2C=CC=CC2=C1)C3=CC(C)=CC=C3
InChI
InChIKey=FUSNMLFNXJSCDI-UHFFFAOYSA-N
InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3
Molecular Formula | C19H17NOS |
Molecular Weight | 307.409 |
Charge | 0 |
Count |
MOL RATIO
1 MOL RATIO (average) |
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Originator
Approval Year
Sourcing
Sample Use Guides
Apply topically to the infected skin as a 1% cream, aerosol liquid spray, aerosol powder spray, powder, or solution.
Route of Administration:
Topical
Ergosterol biosynthesis in fungal cells from Candida albicans, Candida parapsilosis and Trichophyton mentagrophytes was measured by incubation of cells were incubated with [U-14C]acetate at pH 6.5 for 2 hrs and quantification of nonsaponifiable lipids by thin layer chromatography. Tolnaftate inhibited ergosterol biosynthesis with IC50 of about 0.1-1.0 mg/l.