U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Mon Mar 31 21:33:51 GMT 2025
Edited
by admin
on Mon Mar 31 21:33:51 GMT 2025
Protein Type FUSION PROTEINS
Protein Sub Type
Sequence Type COMPLETE
Record UNII
02E00T2QDE
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
eftrenonacog alfa [INN]
Preferred Name English
EFTRENONACOG ALFA
INN   WHO-DD  
INN  
Official Name English
ALPROLIX
Brand Name English
BIIB-029
Code English
BLOOD-COAGULATION FACTOR IX (SYNTHETIC HUMAN) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (SYNTHETIC HUMAN FC DOMAIN FRAGMENT), (421-6'),(424-9')-BIS(DISULFIDE) WITH IMMUNOGLOBULIN G1 (SYNTHETIC HUMAN FC DOMAIN FRAGMENT)
Common Name English
Eftrenonacog alfa [WHO-DD]
Common Name English
RFIXFC
Common Name English
COAGULATION FACTOR IX RECOMBINANT IMMUNOGLUBULIN G1 FUSION PROTEIN
Common Name English
EFTRENONACOG ALFA [MI]
Common Name English
EFTRENONACOG ALFA [JAN]
Common Name English
Classification Tree Code System Code
EU-Orphan Drug EU/3/07/453
Created by admin on Mon Mar 31 21:33:51 GMT 2025 , Edited by admin on Mon Mar 31 21:33:51 GMT 2025
EMA ASSESSMENT REPORTS ALPROLIX (AUTHORIZED: HEMOPHILIA B)
Created by admin on Mon Mar 31 21:33:51 GMT 2025 , Edited by admin on Mon Mar 31 21:33:51 GMT 2025
FDA ORPHAN DRUG 261508
Created by admin on Mon Mar 31 21:33:51 GMT 2025 , Edited by admin on Mon Mar 31 21:33:51 GMT 2025
Code System Code Type Description
MERCK INDEX
m12110
Created by admin on Mon Mar 31 21:33:51 GMT 2025 , Edited by admin on Mon Mar 31 21:33:51 GMT 2025
PRIMARY
DRUG CENTRAL
5084
Created by admin on Mon Mar 31 21:33:51 GMT 2025 , Edited by admin on Mon Mar 31 21:33:51 GMT 2025
PRIMARY
NCI_THESAURUS
C171659
Created by admin on Mon Mar 31 21:33:51 GMT 2025 , Edited by admin on Mon Mar 31 21:33:51 GMT 2025
PRIMARY
FDA UNII
02E00T2QDE
Created by admin on Mon Mar 31 21:33:51 GMT 2025 , Edited by admin on Mon Mar 31 21:33:51 GMT 2025
PRIMARY
IUPHAR
7373
Created by admin on Mon Mar 31 21:33:51 GMT 2025 , Edited by admin on Mon Mar 31 21:33:51 GMT 2025
PRIMARY
SMS_ID
100000159812
Created by admin on Mon Mar 31 21:33:51 GMT 2025 , Edited by admin on Mon Mar 31 21:33:51 GMT 2025
PRIMARY
EVMPD
SUB170597
Created by admin on Mon Mar 31 21:33:51 GMT 2025 , Edited by admin on Mon Mar 31 21:33:51 GMT 2025
PRIMARY
DAILYMED
02E00T2QDE
Created by admin on Mon Mar 31 21:33:51 GMT 2025 , Edited by admin on Mon Mar 31 21:33:51 GMT 2025
PRIMARY
INN
9660
Created by admin on Mon Mar 31 21:33:51 GMT 2025 , Edited by admin on Mon Mar 31 21:33:51 GMT 2025
PRIMARY
CAS
1270012-74-2
Created by admin on Mon Mar 31 21:33:51 GMT 2025 , Edited by admin on Mon Mar 31 21:33:51 GMT 2025
PRIMARY
DRUG BANK
DB11608
Created by admin on Mon Mar 31 21:33:51 GMT 2025 , Edited by admin on Mon Mar 31 21:33:51 GMT 2025
PRIMARY
From To
1_18 1_23
1_51 1_62
1_56 1_71
1_73 1_82
1_88 1_99
1_95 1_109
1_111 1_124
1_132 1_289
1_206 1_222
1_336 1_350
1_361 1_389
1_421 2_6
1_424 2_9
1_456 1_516
1_562 1_620
2_41 2_101
2_147 2_205
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_157
N 1_167
N 1_492
N 2_77
O 1_53
O 1_61
O 1_159
O 1_169
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_155] SITE_SPECIFIC TYROSINE O-SULFATE 29166358BF
AMINO_ACID_SUBSTITUTION [1_64] SITE_SPECIFIC .BETA.-HYDROXY-L-ASPARTIC ACID, THREO- Z9Q5W0U8VW
AMINO_ACID_SUBSTITUTION [1_7] [1_8] [1_15] [1_17] [1_20] [1_21] [1_26] [1_27] [1_30] [1_33] [1_36] [1_40] SITE_SPECIFIC .GAMMA.-CARBOXYGLUTAMIC ACID 16FQV4RZKL
AMINO_ACID_SUBSTITUTION [1_68] [1_158] SITE_SPECIFIC DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL