Siremadlin

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H24Cl2N6O4
Molecular Weight	555.413
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=NC(OC)=C(C=N1)C2=NC3=C([C@@H](N(C3=O)C4=CC(Cl)=CN(C)C4=O)C5=CC=C(Cl)C=C5)N2C(C)C

InChI

InChIKey=AGBSXNCBIWWLHD-FQEVSTJZSA-N

InChI=1S/C26H24Cl2N6O4/c1-13(2)33-21-19(30-22(33)17-11-29-26(38-5)31-23(17)37-4)25(36)34(18-10-16(28)12-32(3)24(18)35)20(21)14-6-8-15(27)9-7-14/h6-13,20H,1-5H3/t20-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C26H24Cl2N6O4
Molecular Weight	555.413
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Tumour suppressor p53/oncoprotein Mdm2 6 Target ID: CHEMBL1907611 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27542305 \| https://patents.google.com/patent/WO2015084804A1/en	Inhibitor 8297		0.13 nM [IC50]

PubMed

Title	Date	PubMed
Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument.	2016 Oct 1	27542305

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:08:33 GMT 2023` Edited by `admin` on `Sat Dec 16 09:08:33 GMT 2023`
Record UNII	0282IF4JC8
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Siremadlin

Official Name

English

NVP-HDM 201

Code

English

HDM201

Code

English

SIREMADLIN [USAN]

Common Name

English

(6S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-(propan-2-yl)-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one

Systematic Name

English

siremadlin [INN]

Common Name

English

Siremadlin [WHO-DD]

Common Name

English

HDM-201

Code

English

Pyrrolo[3,4-d]imidazol-4(1H)-one, 5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-, (6S)-

Systematic Name

English

Code System Code Type Description

FDA UNII

0282IF4JC8