RUZADOLANE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H19F2N5S
Molecular Weight	375.439
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC(F)=C(C=C1)N2CCN(CCSC3=NN=C4C=CC=CN34)CC2

InChI

InChIKey=LOKBLLCVOKCEFR-UHFFFAOYSA-N

InChI=1S/C18H19F2N5S/c19-14-4-5-16(15(20)13-14)24-9-7-23(8-10-24)11-12-26-18-22-21-17-3-1-2-6-25(17)18/h1-6,13H,7-12H2

HIDE SMILES / InChI

Description
Sources: https://adisinsight.springer.com/drugs/800003282 | https://www.ncbi.nlm.nih.gov/pubmed/9706375

Ruzadolane (previously known as UP 26-91) is a serotonin receptor antagonist that was developed as a non-narcotic, centrally acting analgesic agent for the treatment of anxiety disorder and pain. However, these studies were discontinued.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Serotonin 2 (5-HT2) receptor 87 Target ID: CHEMBL2095200 Sources: https://www.hindawi.com/journals/prm/2000/842198/abs/	Antagonist 2778

PubMed

Title	Date	PubMed
Blood and cerebral concentrations of the new potential analgesic UP 26-91 measured in vivo by microdialysis after toxic doses.	1998 Jul	9706375

Name

Type

Language

RUZADOLANE

Official Name

English

UP2691

Code

English

UP 26-91

Code

English

ruzadolane [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C241