RUZADOLANE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H19F2N5S
Molecular Weight	375.439
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC=C(N2CCN(CCSC3=NN=C4C=CC=CN34)CC2)C(F)=C1

InChI

InChIKey=LOKBLLCVOKCEFR-UHFFFAOYSA-N

InChI=1S/C18H19F2N5S/c19-14-4-5-16(15(20)13-14)24-9-7-23(8-10-24)11-12-26-18-22-21-17-3-1-2-6-25(17)18/h1-6,13H,7-12H2

HIDE SMILES / InChI

Molecular Formula	C18H19F2N5S
Molecular Weight	375.439
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800003282 | https://www.ncbi.nlm.nih.gov/pubmed/9706375

Ruzadolane (previously known as UP 26-91) is a serotonin receptor antagonist that was developed as a non-narcotic, centrally acting analgesic agent for the treatment of anxiety disorder and pain. However, these studies were discontinued.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Serotonin 2 (5-HT2) receptor 90 Target ID: CHEMBL2095200 Sources: https://www.hindawi.com/journals/prm/2000/842198/abs/	Antagonist 2849

PubMed

Title	Date	PubMed
Blood and cerebral concentrations of the new potential analgesic UP 26-91 measured in vivo by microdialysis after toxic doses.	1998-07	9706375

Substance Class	Chemical Created by `admin` on `Wed Apr 02 08:45:34 GMT 2025` Edited by `admin` on `Wed Apr 02 08:45:34 GMT 2025`
Record UNII	ZKV3GT35TR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

UP 26-91

Preferred Name

English

RUZADOLANE

Official Name

English

UP2691

Code

English

ruzadolane [INN]

Common Name

English

UP-26-91

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C241