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Details

Stereochemistry ACHIRAL
Molecular Formula C18H19F2N5S.C6H8O7
Molecular Weight 567.562
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RUZADOLANE CITRATE

SMILES

OC(=O)CC(O)(CC(O)=O)C(O)=O.FC1=CC=C(N2CCN(CCSC3=NN=C4C=CC=CN34)CC2)C(F)=C1

InChI

InChIKey=YKNLEKQXHXEQEE-UHFFFAOYSA-N
InChI=1S/C18H19F2N5S.C6H8O7/c19-14-4-5-16(15(20)13-14)24-9-7-23(8-10-24)11-12-26-18-22-21-17-3-1-2-6-25(17)18;7-3(8)1-6(13,5(11)12)2-4(9)10/h1-6,13H,7-12H2;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

HIDE SMILES / InChI
Molecular Formula C18H19F2N5S
Molecular Weight 375.439
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C6H8O7
Molecular Weight 192.1235
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Ruzadolane (previously known as UP 26-91) is a serotonin receptor antagonist that was developed as a non-narcotic, centrally acting analgesic agent for the treatment of anxiety disorder and pain. However, these studies were discontinued.

CNS Activity

Originator

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2849
PubMed

PubMed

TitleDatePubMed
Blood and cerebral concentrations of the new potential analgesic UP 26-91 measured in vivo by microdialysis after toxic doses.
1998-07
Substance Class Chemical
Created
by admin
on Wed Apr 02 20:16:26 GMT 2025
Edited
by admin
on Wed Apr 02 20:16:26 GMT 2025
Record UNII
48H8Q2U5H9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RUZADOLANE CITRATE
Common Name English
UP 26-91 CITRATE
Preferred Name English
1,2,4-Triazolo[4,3-a]pyridine, 3-[[2-[4-(2,4-difluorophenyl)-1-piperazinyl]ethyl]thio]-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
Systematic Name English
Code System Code Type Description
FDA UNII
48H8Q2U5H9
Created by admin on Wed Apr 02 20:16:26 GMT 2025 , Edited by admin on Wed Apr 02 20:16:26 GMT 2025
PRIMARY
CAS
212688-76-1
Created by admin on Wed Apr 02 20:16:26 GMT 2025 , Edited by admin on Wed Apr 02 20:16:26 GMT 2025
PRIMARY
Related Record Type Details
Structure of RUZADOLANE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of RUZADOLANE
ACTIVE MOIETY
NIH
NCATS
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