U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C17H9ClF8N2O4
Molecular Weight 492.705
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NOVALURON

SMILES

FC(OC(F)(F)F)C(F)(F)OC1=C(Cl)C=C(NC(=O)NC(=O)C2=C(F)C=CC=C2F)C=C1

InChI

InChIKey=NJPPVKZQTLUDBO-UHFFFAOYSA-N
InChI=1S/C17H9ClF8N2O4/c18-8-6-7(4-5-11(8)31-16(22,23)14(21)32-17(24,25)26)27-15(30)28-13(29)12-9(19)2-1-3-10(12)20/h1-6,14H,(H2,27,28,29,30)

HIDE SMILES / InChI

Description

Novaluron is an insecticide of the benzoylphenyl urea class that inhibits chitin synthesis, affecting the moulting stages of insect development. It acts by ingestion and contact, and causes abnormal endocuticular deposition and abortive moulting. Novaluron has been registered as an insecticide for food crops and ornamentals in a number of countries. WHO has assessed novaluron for use as a mosquito larvicide in drinking-water in containers, particularly to control dengue fever. The recommended dosage of novaluron in potable water in containers should not exceed 0.05 mg/litre under the WHO Pesticides Evaluation Scheme.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
In a test for acute oral toxicity, five male and five female mice (strain Hsd/Ola:ICR) were given novaluron (purity, 99.3%) at a limit dose of 5000 mg/kg bw (20 ml/kg) by gavage in distilled water. There were no mortalities or clinical signs of toxicity.
Route of Administration: Oral
In Vitro Use Guide
Human lymphocytes were cultured with 0-5000 ug/mL of Novaluron. Genotoxicity test results were negative.