Halquinols (halquinol) is an antimicrobial for treatment of skin infections available as topical skin pharmaceutical. Tarquinor skin cream, a dermatological preparation of halquinol 0.2% and 1% coal tar has been approved for use in New Zealand in 1962 and is in use in Australia at present. Halquinols has a broad antimicrobial activity in vitro against a wide variety of bacteria, fungi and protozoa including Candida albicans, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus pyogenes. It has a significant antimycoplasmal (MICs of 3 to 4 ug/ml) and anticryptosporidial activity at 1 or 20 uM against Cryptosporidium parvum. As some antimicrobials halquinol has been used as a growth promotor in poultry. Study of fresh water fish Catla catla treated with halquinol suggested enhanced anabolic metabolism resulting in weight gain. However, the mechanisms by which the drug improves performance are not fully understood. Halquinol was the only antimicrobial drug tested in chicken that did not affect microbial membership compared to the control group.
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/263891 | http://www.trademarkia.com/au/trademark-112493.htm
Curator's Comment: In December 17, 1952 the an Australia trademark registration was filed for TARQUINOR by E R Squibb & Sons Inc a Delaware corporation Lawrenceville-Princeton Road, Princeton, New Jersey 08540. The Australia IP office has given the trademark application number of 112493. The current status of this trademark filing is Removed - Not Renewed
Approval Year
PubMed
Title | Date | PubMed |
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[A new preparation of coal tar and chlorhydroxyquinoline; therapeutic trial]. | 1954 Dec 17 |
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In vitro activity of chlorhydroxyquinoline against mycoplasma species. | 1978 Mar |
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Neuropathy and optic atrophy associted with halquinol. | 1981 Feb 21 |
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Assessment of drugs against Cryptosporidium parvum using a simple in vitro screening method. | 1999 Sep 15 |
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Sulfate transport mechanisms in epithelial systems. | 2001 Apr 1 |
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Antimicrobial activity of topical skin pharmaceuticals - an in vitro study. | 2010 May |
Sample Use Guides
In Vivo Use Guide
Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D04415
Unknown
Route of Administration:
Topical
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/263891
The in vitro activities of 5-chloro-8-hydroxyquinoline (CHQ, Halquinols) against single strains of 12 different species of mycoplasma and the impacts of repeated exposure of these strains to CHQ on their susceptibility to this agent have been studied. On initial exposure, the minimal inhibitory concentrations for these strains ranged from 0.24 to 1.92 micrograms of CHQ per ml of test medium; activities remained unchanged during 10 serial transfers in CHQ-containing medium.
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SUBSTANCE RECORD