U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Halquinols (halquinol) is an antimicrobial for treatment of skin infections available as topical skin pharmaceutical. Tarquinor skin cream, a dermatological preparation of halquinol 0.2% and 1% coal tar has been approved for use in New Zealand in 1962 and is in use in Australia at present. Halquinols has a broad antimicrobial activity in vitro against a wide variety of bacteria, fungi and protozoa including Candida albicans, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus pyogenes. It has a significant antimycoplasmal (MICs of 3 to 4 ug/ml) and anticryptosporidial activity at 1 or 20 uM against Cryptosporidium parvum. As some antimicrobials halquinol has been used as a growth promotor in poultry. Study of fresh water fish Catla catla treated with halquinol suggested enhanced anabolic metabolism resulting in weight gain. However, the mechanisms by which the drug improves performance are not fully understood. Halquinol was the only antimicrobial drug tested in chicken that did not affect microbial membership compared to the control group.

Originator

Curator's Comment: In December 17, 1952 the an Australia trademark registration was filed for TARQUINOR by E R Squibb & Sons Inc a Delaware corporation Lawrenceville-Princeton Road, Princeton, New Jersey 08540. The Australia IP office has given the trademark application number of 112493. The current status of this trademark filing is Removed - Not Renewed

Approval Year

Conditions

Conditions

PubMed

PubMed

TitleDatePubMed
In vitro activity of chlorhydroxyquinoline against mycoplasma species.
1978 Mar
Report prepared by the Medicinal Additives in Animal Feeds Sub-Committee (B). Determination of halquinol (chloroquinolin-8-ols) in pre-mixes and medicated feeding stuffs.
1981 Jan
[Clinical use of Chinoderm ointments 0.2% and 1% in various bases].
1981 May 1
Sulfate transport mechanisms in epithelial systems.
2001 Apr 1

Sample Use Guides

Unknown
Route of Administration: Topical
In Vitro Use Guide
The in vitro activities of 5-chloro-8-hydroxyquinoline (CHQ, Halquinols) against single strains of 12 different species of mycoplasma and the impacts of repeated exposure of these strains to CHQ on their susceptibility to this agent have been studied. On initial exposure, the minimal inhibitory concentrations for these strains ranged from 0.24 to 1.92 micrograms of CHQ per ml of test medium; activities remained unchanged during 10 serial transfers in CHQ-containing medium.
Substance Class Mixture
Created
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Record UNII
Z7Z4BX535U
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Name Type Language
HALQUINOLS
USAN  
USAN  
Official Name English
HALQUINOLS [USAN]
Common Name English
5,7-Dichloro-8-quinolinol mixt. with 5-chloro-8-quinolinol and 7-chloro-8-quinolinol
Common Name English
HALQUINOL
MART.   MI   WHO-DD  
Common Name English
Halquinol [WHO-DD]
Common Name English
8-QUINOLINOL, 5,7-DICHLORO-, MIXT. WITH 5-CHLORO-8-QUINOLINOL AND 7-CHLORO-8-QUINOLINOL
Common Name English
5,7-DICHLORO-8-QUINOLINOL, 5-CHLORO-8-QUINOLINOL, AND 7-CHLORO-8-QUINOLINOL IN PROPORTIONS RESULTING NATURALLY FROM CHLORINATION OF 8-QUINOLINOL
Common Name English
HALQUINOL [MART.]
Common Name English
SQ-16401
Code English
HALQUINOL [MI]
Common Name English
QUINOLOR
Brand Name English
SQ 16,401
Code English
Code System Code Type Description
NCI_THESAURUS
C170039
Created by admin on Fri Dec 15 17:34:11 GMT 2023 , Edited by admin on Fri Dec 15 17:34:11 GMT 2023
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MESH
C011838
Created by admin on Fri Dec 15 17:34:11 GMT 2023 , Edited by admin on Fri Dec 15 17:34:11 GMT 2023
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MERCK INDEX
m227
Created by admin on Fri Dec 15 17:34:11 GMT 2023 , Edited by admin on Fri Dec 15 17:34:11 GMT 2023
PRIMARY Merck Index
EVMPD
SUB14056MIG
Created by admin on Fri Dec 15 17:34:11 GMT 2023 , Edited by admin on Fri Dec 15 17:34:11 GMT 2023
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CAS
8067-69-4
Created by admin on Fri Dec 15 17:34:11 GMT 2023 , Edited by admin on Fri Dec 15 17:34:11 GMT 2023
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EPA CompTox
DTXSID90230490
Created by admin on Fri Dec 15 17:34:11 GMT 2023 , Edited by admin on Fri Dec 15 17:34:11 GMT 2023
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FDA UNII
Z7Z4BX535U
Created by admin on Fri Dec 15 17:34:11 GMT 2023 , Edited by admin on Fri Dec 15 17:34:11 GMT 2023
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Definition References