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Details

Stereochemistry ACHIRAL
Molecular Formula C9H5Cl2NO
Molecular Weight 214.048
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHLOROXINE

SMILES

OC1=C2N=CC=CC2=C(Cl)C=C1Cl

InChI

InChIKey=WDFKMLRRRCGAKS-UHFFFAOYSA-N
InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H

HIDE SMILES / InChI

Molecular Formula C9H5Cl2NO
Molecular Weight 214.048
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Chloroxine, a dichloroquinolinol, was first prepared by A. Hebebrand in 1888. It is an antibacterial drug that has been incorporated into shampoos to treat dandruff and seborrheic dermatitis. It has also been used internally as an antidiarrheal and in the lab as an analytical reagent. The drug was withdrawn from the market in the US by unknown reason.

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
CAPITROL

Cmax

ValueDoseCo-administeredAnalytePopulation
0.713 μg/g
2 μL single, oral
CHLOROXINE plasma
Oryctolagus cuniculus

AUC

ValueDoseCo-administeredAnalytePopulation
60.72 μg × min/mL
2 μL single, oral
CHLOROXINE plasma
Oryctolagus cuniculus

T1/2

ValueDoseCo-administeredAnalytePopulation
48.72 min
2 μL single, oral
CHLOROXINE plasma
Oryctolagus cuniculus

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
Apply onto the wet scalp, leave on for approximately three minutes, then rinse.
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
2I8BD50I8B
Record Status Validated (UNII)
Record Version