LAVOLTIDINE SUCCINATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	2C19H29N5O2.C4H6O4
Molecular Weight	837.0198
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CCC(O)=O.CN1N=C(CO)N=C1NCCCOC2=CC=CC(CN3CCCCC3)=C2.CN4N=C(CO)N=C4NCCCOC5=CC=CC(CN6CCCCC6)=C5

InChI

InChIKey=IRLVOMNMSKSKMH-UHFFFAOYSA-N

InChI=1S/2C19H29N5O2.C4H6O4/c2*1-23-19(21-18(15-25)22-23)20-9-6-12-26-17-8-5-7-16(13-17)14-24-10-3-2-4-11-24;5-3(6)1-2-4(7)8/h2*5,7-8,13,25H,2-4,6,9-12,14-15H2,1H3,(H,20,21,22);1-2H2,(H,5,6)(H,7,8)

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6145595 | https://www.ncbi.nlm.nih.gov/pubmed/4041682 | https://www.ncbi.nlm.nih.gov/pubmed/2878860

LAVOLTIDINE, also known as loxtidine, is a highly potent and selective histamine H2-receptor antagonist. It is a member of triazoles. It produces gastric carcinoid tumors in rodents that is why its clinical development was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
The CCK(2) receptor antagonist, YF476, inhibits Mastomys ECL cell hyperplasia and gastric carcinoid tumor development.	2010 Jun 8	20144901

Name

Type

Language

LAVOLTIDINE SUCCINATE

Official Name

English

LAVOLTIDINE SUCCINATE [USAN]

Common Name

English

AH 23844 HEMISUCCINATE

Code

English

AH-23844 HEMISUCCINATE

Code

English

1-METHYL-5-((3-((.ALPHA.-PIPERIDINO-M-TOLYL)OXY)PROPYL)AMINO)-1H-1,2,4-TRIAZOLE-3-METHANOL SUCCINATE (2:1) (SALT)

Systematic Name

English

LOXOTIDINE SUCCINATE

Common Name

English

AH-23844A

Code

English

1-METHYL-5-((3-(3-(1-PIPERIDINYLMETHYL)PHENOXY)PROPYL)AMINO)-1H-1,2,4-TRIAZOLE-3-METHANOL

Systematic Name

English

AH 23844A

Code

English

1H-1,2,4-TRIAZOLE-3-METHANOL, 1-METHYL-5-((3-(3-(1-PIPERIDINYLMETHYL)PHENOXY)PROPYL)AMINO)-, BUTANEDIOATE (2:1) (SALT)

Systematic Name

English

Code System Code Type Description

NCI_THESAURUS

C170099