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Details

Stereochemistry ACHIRAL
Molecular Formula 2C19H29N5O2.C4H6O4
Molecular Weight 837.0198
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LAVOLTIDINE SUCCINATE

SMILES

OC(=O)CCC(O)=O.CN1N=C(CO)N=C1NCCCOC2=CC=CC(CN3CCCCC3)=C2.CN4N=C(CO)N=C4NCCCOC5=CC=CC(CN6CCCCC6)=C5

InChI

InChIKey=IRLVOMNMSKSKMH-UHFFFAOYSA-N
InChI=1S/2C19H29N5O2.C4H6O4/c2*1-23-19(21-18(15-25)22-23)20-9-6-12-26-17-8-5-7-16(13-17)14-24-10-3-2-4-11-24;5-3(6)1-2-4(7)8/h2*5,7-8,13,25H,2-4,6,9-12,14-15H2,1H3,(H,20,21,22);1-2H2,(H,5,6)(H,7,8)

HIDE SMILES / InChI

Molecular Formula C4H6O4
Molecular Weight 118.088
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C19H29N5O2
Molecular Weight 359.4659
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

LAVOLTIDINE, also known as loxtidine, is a highly potent and selective histamine H2-receptor antagonist. It is a member of triazoles. It produces gastric carcinoid tumors in rodents that is why its clinical development was discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer.
2005 Jun
Gastrin-induced apoptosis contributes to carcinogenesis in the stomach.
2006 Oct
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:35:40 UTC 2023
Edited
by admin
on Fri Dec 15 15:35:40 UTC 2023
Record UNII
YSJ55YKG2J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LAVOLTIDINE SUCCINATE
USAN  
USAN  
Official Name English
LAVOLTIDINE SUCCINATE [USAN]
Common Name English
AH 23844 HEMISUCCINATE
Code English
AH-23844 HEMISUCCINATE
Code English
1-METHYL-5-((3-((.ALPHA.-PIPERIDINO-M-TOLYL)OXY)PROPYL)AMINO)-1H-1,2,4-TRIAZOLE-3-METHANOL SUCCINATE (2:1) (SALT)
Systematic Name English
LOXOTIDINE SUCCINATE
Common Name English
AH-23844A
Code English
1-METHYL-5-((3-(3-(1-PIPERIDINYLMETHYL)PHENOXY)PROPYL)AMINO)-1H-1,2,4-TRIAZOLE-3-METHANOL
Systematic Name English
AH 23844A
Code English
1H-1,2,4-TRIAZOLE-3-METHANOL, 1-METHYL-5-((3-(3-(1-PIPERIDINYLMETHYL)PHENOXY)PROPYL)AMINO)-, BUTANEDIOATE (2:1) (SALT)
Systematic Name English
Code System Code Type Description
NCI_THESAURUS
C170099
Created by admin on Fri Dec 15 15:35:40 UTC 2023 , Edited by admin on Fri Dec 15 15:35:40 UTC 2023
PRIMARY
USAN
BB-34
Created by admin on Fri Dec 15 15:35:40 UTC 2023 , Edited by admin on Fri Dec 15 15:35:40 UTC 2023
PRIMARY
FDA UNII
YSJ55YKG2J
Created by admin on Fri Dec 15 15:35:40 UTC 2023 , Edited by admin on Fri Dec 15 15:35:40 UTC 2023
PRIMARY
ChEMBL
CHEMBL2110857
Created by admin on Fri Dec 15 15:35:40 UTC 2023 , Edited by admin on Fri Dec 15 15:35:40 UTC 2023
PRIMARY
PUBCHEM
55472
Created by admin on Fri Dec 15 15:35:40 UTC 2023 , Edited by admin on Fri Dec 15 15:35:40 UTC 2023
PRIMARY
EPA CompTox
DTXSID50235426
Created by admin on Fri Dec 15 15:35:40 UTC 2023 , Edited by admin on Fri Dec 15 15:35:40 UTC 2023
PRIMARY
CAS
86160-82-9
Created by admin on Fri Dec 15 15:35:40 UTC 2023 , Edited by admin on Fri Dec 15 15:35:40 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY