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Details

Stereochemistry ACHIRAL
Molecular Formula C19H25NO.BrH
Molecular Weight 364.32
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ALENTEMOL HYDROBROMIDE

SMILES

Br.CCCN(CCC)C1CC2=CC(O)=CC3=CC=CC(C1)=C23

InChI

InChIKey=FWRWEZVGVJKNMU-UHFFFAOYSA-N
InChI=1S/C19H25NO.BrH/c1-3-8-20(9-4-2)17-10-14-6-5-7-15-12-18(21)13-16(11-17)19(14)15;/h5-7,12-13,17,21H,3-4,8-11H2,1-2H3;1H

HIDE SMILES / InChI
Alentemol (U-66444B) is a selective dopamine agonist acting at presynaptic receptors to inhibit the release of dopamine. In preclinical studies the compound caused hypothermia in mice and inhibited amphetamine-stimulated omtor activity in mice. U-66444B was investigated by Upjohn Company for the treatment of schizophrenia, but the development of the drug was discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
U-66444B and U-68553B, potent autoreceptor agonists at dopaminergic cell bodies and terminals.
1990 Aug
Determination of alentamol hydrobromide, a novel antipsychotic agent, in human blood plasma and urine by high-performance liquid chromatography with fluorescence detection and solid-phase extraction.
1991 Apr 19
Patents
Name Type Language
ALENTEMOL HYDROBROMIDE
USAN  
USAN  
Official Name English
U-68,553B
Code English
1H-PHENALEN-5-OL, 2-(DIPROPYLAMINO)-2,3-DIHYDRO-, HYDROBROMIDE, (+)-
Systematic Name English
(+)-2-(DIPROPYLAMINO)-2,3-DIHYDROPHENALEN-5-OL HBR
Common Name English
(+)-2-(DIPROPYLAMINO)-2,3-DIHYDROPHENALEN-5-OL HYDROBROMIDE
Systematic Name English
1H-PHENALEN-5-OL, 2-(DIPROPYLAMINO)-2,3-DIHYDRO-, HBR, (+)-
Common Name English
U-68553B
Code English
ALENTEMOL HBR
Common Name English
ALENTEMOL HYDROBROMIDE [USAN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C66884
Created by admin on Fri Dec 15 16:06:51 GMT 2023 , Edited by admin on Fri Dec 15 16:06:51 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID90920940
Created by admin on Fri Dec 15 16:06:51 GMT 2023 , Edited by admin on Fri Dec 15 16:06:51 GMT 2023
PRIMARY
NCI_THESAURUS
C80087
Created by admin on Fri Dec 15 16:06:51 GMT 2023 , Edited by admin on Fri Dec 15 16:06:51 GMT 2023
PRIMARY
USAN
BB-17
Created by admin on Fri Dec 15 16:06:51 GMT 2023 , Edited by admin on Fri Dec 15 16:06:51 GMT 2023
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PUBCHEM
60573
Created by admin on Fri Dec 15 16:06:51 GMT 2023 , Edited by admin on Fri Dec 15 16:06:51 GMT 2023
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ChEMBL
CHEMBL2104081
Created by admin on Fri Dec 15 16:06:51 GMT 2023 , Edited by admin on Fri Dec 15 16:06:51 GMT 2023
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CAS
112892-81-6
Created by admin on Fri Dec 15 16:06:51 GMT 2023 , Edited by admin on Fri Dec 15 16:06:51 GMT 2023
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FDA UNII
Y67FY3RWN1
Created by admin on Fri Dec 15 16:06:51 GMT 2023 , Edited by admin on Fri Dec 15 16:06:51 GMT 2023
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