Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H25NO |
| Molecular Weight | 283.4079 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCN(CCC)C1CC2=CC=CC3=CC(O)=CC(C1)=C23
InChI
InChIKey=TWUJBHBRYYTEDL-UHFFFAOYSA-N
InChI=1S/C19H25NO/c1-3-8-20(9-4-2)17-10-14-6-5-7-15-12-18(21)13-16(11-17)19(14)15/h5-7,12-13,17,21H,3-4,8-11H2,1-2H3
| Molecular Formula | C19H25NO |
| Molecular Weight | 283.4079 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Alentemol (U-66444B) is a selective dopamine agonist acting at presynaptic receptors to inhibit the release of dopamine. In preclinical studies the compound caused hypothermia in mice and inhibited amphetamine-stimulated omtor activity in mice. U-66444B was investigated by Upjohn Company for the treatment of schizophrenia, but the development of the drug was discontinued.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| U-66444B and U-68553B, potent autoreceptor agonists at dopaminergic cell bodies and terminals. | 1990 Aug |
|
| Determination of alentamol hydrobromide, a novel antipsychotic agent, in human blood plasma and urine by high-performance liquid chromatography with fluorescence detection and solid-phase extraction. | 1991 Apr 19 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:17:40 GMT 2023
by
admin
on
Fri Dec 15 16:17:40 GMT 2023
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| Record UNII |
F6S91MHL3E
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| Record Status |
Validated (UNII)
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| Record Version |
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| Name | Type | Language | ||
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Official Name | English | ||
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Common Name | English | ||
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Systematic Name | English |
| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C66884
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| Code System | Code | Type | Description | ||
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100000087852
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SUB05308MIG
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CHEMBL2104081
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Alentemol
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112891-97-1
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6755
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DTXSID80869556
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C77562
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60574
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F6S91MHL3E
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
