ALENTEMOL HYDROBROMIDE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H25NO.BrH
Molecular Weight	364.32
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Br.CCCN(CCC)C1CC2=CC(O)=CC3=CC=CC(C1)=C23

InChI

InChIKey=FWRWEZVGVJKNMU-UHFFFAOYSA-N

InChI=1S/C19H25NO.BrH/c1-3-8-20(9-4-2)17-10-14-6-5-7-15-12-18(21)13-16(11-17)19(14)15;/h5-7,12-13,17,21H,3-4,8-11H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula	BrH
Molecular Weight	80.912
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C19H25NO
Molecular Weight	283.4079
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://onlinelibrary.wiley.com/doi/abs/10.1002/ddr.430170108 | https://www.ncbi.nlm.nih.gov/pubmed/1874898 | https://adisinsight.springer.com/drugs/800001481

Alentemol (U-66444B) is a selective dopamine agonist acting at presynaptic receptors to inhibit the release of dopamine. In preclinical studies the compound caused hypothermia in mice and inhibited amphetamine-stimulated omtor activity in mice. U-66444B was investigated by Upjohn Company for the treatment of schizophrenia, but the development of the drug was discontinued.

Approval Year

PubMed

Title	Date	PubMed
U-66444B and U-68553B, potent autoreceptor agonists at dopaminergic cell bodies and terminals.	1990 Aug	1974631
Determination of alentamol hydrobromide, a novel antipsychotic agent, in human blood plasma and urine by high-performance liquid chromatography with fluorescence detection and solid-phase extraction.	1991 Apr 19	1874898

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:06:51 GMT 2023` Edited by `admin` on `Fri Dec 15 16:06:51 GMT 2023`
Record UNII	Y67FY3RWN1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ALENTEMOL HYDROBROMIDE

Official Name

English

U-68,553B

Code

English

1H-PHENALEN-5-OL, 2-(DIPROPYLAMINO)-2,3-DIHYDRO-, HYDROBROMIDE, (+)-

Systematic Name

English

(+)-2-(DIPROPYLAMINO)-2,3-DIHYDROPHENALEN-5-OL HBR

Common Name

English

(+)-2-(DIPROPYLAMINO)-2,3-DIHYDROPHENALEN-5-OL HYDROBROMIDE

Systematic Name

English

1H-PHENALEN-5-OL, 2-(DIPROPYLAMINO)-2,3-DIHYDRO-, HBR, (+)-

Common Name

English

U-68553B

Code

English

ALENTEMOL HBR

Common Name

English

ALENTEMOL HYDROBROMIDE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66884