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Details

Stereochemistry UNKNOWN
Molecular Formula C17H15ClN2O
Molecular Weight 298.767
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CICLAZINDOL

SMILES

OC1(C2=NCCCN2C3=C1C=CC=C3)C4=CC=CC(Cl)=C4

InChI

InChIKey=VKQDZNZTPGLGFD-UHFFFAOYSA-N
InChI=1S/C17H15ClN2O/c18-13-6-3-5-12(11-13)17(21)14-7-1-2-8-15(14)20-10-4-9-19-16(17)20/h1-3,5-8,11,21H,4,9-10H2

HIDE SMILES / InChI
Ciclazindol is an indole derivative and monoamine uptake inhibitor patented by pharmaceutical company John Wyeth and Brother Ltd. as an antidepressant. Besides that, Ciclazindol is effective anorectic agent, inducing weight loss in rats and man. Ciclazindol was shown to inhibit ATP-sensitive K+ (K(ATP)) channel currents and stimulate insulin secretion from CRI-G1 insulin-secreting cells. The inhibition of KATP channel currents by ciclazindol is unaffected by the removal of intracellular Mg2+ ions and after trypsinization of the cytoplasmic surface of excised patches, treatments known to abolish sulphonylurea sensitivity.

Approval Year

PubMed

PubMed

TitleDatePubMed
The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1.
2004 Aug 24
Patents

Patents

Name Type Language
CICLAZINDOL
INN   USAN  
INN   USAN  
Official Name English
WY-23409
Code English
CICLAZINDOL [USAN]
Common Name English
PYRIMIDO(1,2-A)INDOL-10-OL, 10-(3-CHLOROPHENYL)-2,3,4,10-TETRAHYDRO-
Systematic Name English
10-(M-CHLOROPHENYL)-2,3,4,10-TETRAHYDROPYRIMIDO(1,2-A)INDOL-10-OL
Systematic Name English
ciclazindol [INN]
Common Name English
WY-23,409
Code English
Classification Tree Code System Code
NCI_THESAURUS C265
Created by admin on Fri Dec 15 16:09:17 GMT 2023 , Edited by admin on Fri Dec 15 16:09:17 GMT 2023
Code System Code Type Description
CAS
37751-39-6
Created by admin on Fri Dec 15 16:09:17 GMT 2023 , Edited by admin on Fri Dec 15 16:09:17 GMT 2023
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WIKIPEDIA
Ciclazindol
Created by admin on Fri Dec 15 16:09:17 GMT 2023 , Edited by admin on Fri Dec 15 16:09:17 GMT 2023
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USAN
Y-8
Created by admin on Fri Dec 15 16:09:17 GMT 2023 , Edited by admin on Fri Dec 15 16:09:17 GMT 2023
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NCI_THESAURUS
C79886
Created by admin on Fri Dec 15 16:09:17 GMT 2023 , Edited by admin on Fri Dec 15 16:09:17 GMT 2023
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MESH
C009990
Created by admin on Fri Dec 15 16:09:17 GMT 2023 , Edited by admin on Fri Dec 15 16:09:17 GMT 2023
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PUBCHEM
37825
Created by admin on Fri Dec 15 16:09:17 GMT 2023 , Edited by admin on Fri Dec 15 16:09:17 GMT 2023
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EPA CompTox
DTXSID50865883
Created by admin on Fri Dec 15 16:09:17 GMT 2023 , Edited by admin on Fri Dec 15 16:09:17 GMT 2023
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EVMPD
SUB06235MIG
Created by admin on Fri Dec 15 16:09:17 GMT 2023 , Edited by admin on Fri Dec 15 16:09:17 GMT 2023
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SMS_ID
100000081884
Created by admin on Fri Dec 15 16:09:17 GMT 2023 , Edited by admin on Fri Dec 15 16:09:17 GMT 2023
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FDA UNII
Y3I9520J7P
Created by admin on Fri Dec 15 16:09:17 GMT 2023 , Edited by admin on Fri Dec 15 16:09:17 GMT 2023
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ChEMBL
CHEMBL1192491
Created by admin on Fri Dec 15 16:09:17 GMT 2023 , Edited by admin on Fri Dec 15 16:09:17 GMT 2023
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INN
3900
Created by admin on Fri Dec 15 16:09:17 GMT 2023 , Edited by admin on Fri Dec 15 16:09:17 GMT 2023
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