JNJ-42165279 HYDROCHLORIDE

Investigational

Cl.FC1(F)OC2=CC=C(CN3CCN(CC3)C(=O)NC4=C(Cl)C=CN=C4)C=C2O1

InChIKey=QXRBSEFDVGDHGV-UHFFFAOYSA-N

InChI=1S/C18H17ClF2N4O3.ClH/c19-13-3-4-22-10-14(13)23-17(26)25-7-5-24(6-8-25)11-12-1-2-15-16(9-12)28-18(20,21)27-15;/h1-4,9-10H,5-8,11H2,(H,23,26);1H

Targets

Primary Target	Pharmacology	Condition	Potency
Anandamide amidohydrolase 27 Target ID: CHEMBL2243 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26713105 \| https://patents.google.com/patent/WO2011139951A1	Inhibitor 8504		70.0 nM [IC50]

PubMed

Title	Date	PubMed
Fatty Acid Amide Hydrolase Inhibition by JNJ-42165279: A Multiple-Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers.	2018-07	29575526
Preclinical Characterization of the FAAH Inhibitor JNJ-42165279.	2015-12-10	26713105

Patents

Name

Type

Language

1-PIPERAZINECARBOXAMIDE, N-(4-CHLORO-3-PYRIDINYL)-4-((2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYL)-, HYDROCHLORIDE (1:1)

Preferred Name

English

JNJ-42165279 HYDROCHLORIDE

Code

English

Code System Code Type Description

SMS_ID

300000051575

Created by admin on Tue Apr 01 22:42:10 GMT 2025 , Edited by admin on Tue Apr 01 22:42:10 GMT 2025

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CAS

1346528-52-6

Created by admin on Tue Apr 01 22:42:10 GMT 2025 , Edited by admin on Tue Apr 01 22:42:10 GMT 2025

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FDA UNII

Y23WF20TS1

Created by admin on Tue Apr 01 22:42:10 GMT 2025 , Edited by admin on Tue Apr 01 22:42:10 GMT 2025

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PUBCHEM

67465468

Created by admin on Tue Apr 01 22:42:10 GMT 2025 , Edited by admin on Tue Apr 01 22:42:10 GMT 2025

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ACTIVE MOIETY


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SUBSTANCE RECORD


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