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Details

Stereochemistry ACHIRAL
Molecular Formula Mg.O2
Molecular Weight 56.3038
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MAGNESIUM PEROXIDE

SMILES

[Mg++].[O-][O-]

InChI

InChIKey=SPAGIJMPHSUYSE-UHFFFAOYSA-N
InChI=1S/Mg.O2/c;1-2/q+2;-2

HIDE SMILES / InChI

Description

Hydrogen peroxide has been used in medicine for more than 100 years. It is known in surgery as a highly useful irrigation solution by virtue of both its hemostatic and its antimicrobial effects. Hydrogen peroxide is a mild antiseptic used on the skin to prevent infection of minor cuts, scrapes, and burns. It may also be used as a mouth rinse to help remove mucus or to relieve minor mouth irritation (e.g., due to canker/cold sores, gingivitis). This product works by releasing oxygen when it is applied to the affected area. The release of oxygen causes foaming, which helps to remove dead skin and clean the area. Hydrogen peroxide is a strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.

CNS Activity

Originator

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Modulator
828
Agonist
2678
 4.54 null [pEC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
ESKATA

Approved Use

ESKATA is indicated for the treatment of seborrheic keratoses that are raised.

Launch Date

2017
Preventing
Approved
8429
Hydrogen Peroxide Solution

Approved Use

Uses of Hydrogen Peroxide Solution: It is used to prevent skin infections. It is used to help get rid of phlegm or mucus or help with a sore mouth.
Primary
Approved
8429
Hydrogen Peroxide Solution

Approved Use

Hydrogen peroxide is a mild antiseptic used on the skin to prevent infection of minor cuts, scrapes, and burns. It may also be used as a mouth rinse to help remove mucus or to relieve minor mouth irritation (e.g., due to canker/cold sores, gingivitis).

Launch Date

1982
PubMed

PubMed

TitleDatePubMed
Critical role of sulfenic acid formation of thiols in the inactivation of glyceraldehyde-3-phosphate dehydrogenase by nitric oxide.
1999 Jul 1
Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity.
1999 Oct 1
Inhibition of glomerular cell apoptosis by heparin.
1999 Sep
Activation of JNK, p38 and ERK mitogen-activated protein kinases by chromium(VI) is mediated through oxidative stress but does not affect cytotoxicity.
2000 Aug
Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils.
2000 Feb 1
Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide.
2000 Feb 18
Class A scavenger receptor up-regulation in smooth muscle cells by oxidized low density lipoprotein. Enhancement by calcium flux and concurrent cyclooxygenase-2 up-regulation.
2000 Jun 9
Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress.
2000 Mar
Reactive oxygen species and proinflammatory cytokine signaling in endothelial cells: effect of selenium supplementation.
2000 Mar 15
Neurons and astrocytes express EPO mRNA: oxygen-sensing mechanisms that involve the redox-state of the brain.
2000 May
Role of antioxidant systems in human androgen-independent prostate cancer cells.
2000 May 1
Redox state dependency of HERGS631C channel pharmacology: relation to C-type inactivation.
2000 May 26
Vanadate induces p53 transactivation through hydrogen peroxide and causes apoptosis.
2000 Oct 20
Mitochondrial-derived oxidants and quartz activation of chemokine gene expression.
2001
Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation.
2001 Dec
NF kappa B and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells.
2001 Dec 1
Increased 15-HPETE production decreases prostacyclin synthase activity during oxidant stress in aortic endothelial cells.
2001 Feb 1
Hyperoxia inhibits oxidant-induced apoptosis in lung epithelial cells.
2001 Jan 5
Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells.
2001 Jul 6
IL-4 gene expression up-regulated by mercury in rat mast cells: a role of oxidant stress in IL-4 transcription.
2001 Mar
Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins.
2001 May
The influence of oxidative stress on catalase and MnSOD gene transcription in astrocytes.
2001 May 4
p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line.
2001 Nov
Reactive oxygen species mediate cyclic strain-induced endothelin-1 gene expression via Ras/Raf/extracellular signal-regulated kinase pathway in endothelial cells.
2001 Oct
Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway.
2001 Oct
Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death.
2001 Oct 9
High glucose stimulates angiotensinogen gene expression via reactive oxygen species generation in rat kidney proximal tubular cells.
2002 Aug
Overexpression of human metallothionein-III prevents hydrogen peroxide-induced oxidative stress in human fibroblasts.
2002 Jun 19
Protein overload-induced NF-kappaB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway.
2002 May
Differential expression of two stress-inducible hsp70 genes by various stressors.
2002 May 31
Doxorubicin-induced apoptosis: implications in cardiotoxicity.
2002 May-Jun
The antioxidant cocktail effective microorganism X (EM-X) inhibits oxidant-induced interleukin-8 release and the peroxidation of phospholipids in vitro.
2002 Sep 6
Patents

Patents

03931169
4
03932472
94
03947406
32
03952001
6
03985796
4
04007276
7
04012430
5
04022769
14
04023926
4
04028278
4
04036988
4
04039685
4
04042773
4
04062875
4
04064135
4
04083983
6
04098816
16
04100280
5
04115584
8
04148918
8
04153716
4
04163789
5
04168379
7
04170704
9
04172945
10
04180518
6
20040162406
4
6639031
4

Sample Use Guides

In Vivo Use Guide
Topical solution: 40% (w/w) hydrogen peroxide. Apply 4 times, approximately 1 minute apart, to the targeted lesion(s) during a single in-office treatment session.
Route of Administration: Topical
In Vitro Use Guide
Hydrogen peroxide (H2O2, 100-500 uM) caused a concentration-dependent decrease in the activity of recombinant mouse 3-MST enzyme. In mitochondria isolated from murine hepatoma cells, H2O2 (50-500 uM) caused a concentration-dependent decrease in production of H2S from 3-MP. In cultured murine hepatoma cells H2O2, (3-100 uM), did not result in overall cytotoxicity, but caused a partial decrease in basal oxygen consumption and respiratory reserve rapacity. The positive bioenergetic effect of 3-MP (100-300 nM) was completely abolished by pre-treatment of the cells with H2O2 (50 uM).
Name Type Language
MAGNESIUM PEROXIDE
EP   INCI   MART.   MI   WHO-DD  
INCI  
Official Name English
MAGNESIUM PERHYDROL
Common Name English
MAGNESIUM DIOXIDE
Common Name English
MAGNESIUM PEROXIDE [MI]
Common Name English
MAGNESIUM PEROXIDE [WHO-DD]
Common Name English
MAGNESIUM PEROXIDE [INCI]
Common Name English
MAGNESIUM PEROXIDE [MART.]
Common Name English
MAGNESIUM PEROXIDE (MG(O2))
Systematic Name English
DRILLOX M
Brand Name English
MAGNESIUM SUPEROXOL
Brand Name English
MAGNESIUM PEROXIDE [EP MONOGRAPH]
Common Name English
Classification Tree Code System Code
WHO-VATC QA02AA03
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
WHO-VATC QA06AD03
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
WHO-ATC A02AA03
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
WHO-ATC A06AD03
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
Code System Code Type Description
EVMPD
SUB14439MIG
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
PRIMARY
DRUG BANK
DB13486
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
PRIMARY
RXCUI
1666106
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
PRIMARY RxNorm
SMS_ID
100000076807
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
PRIMARY
DAILYMED
X8YVJ0TN96
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
PRIMARY
ECHA (EC/EINECS)
238-438-1
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
PRIMARY
MESH
C517394
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
PRIMARY
MERCK INDEX
m7014
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
PRIMARY Merck Index
CAS
14452-57-4
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
PRIMARY
WIKIPEDIA
MAGNESIUM PEROXIDE
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
PRIMARY
FDA UNII
X8YVJ0TN96
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
PRIMARY
HSDB
7986
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
PRIMARY
CAS
1312-95-4
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
SUPERSEDED
DRUG CENTRAL
4595
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
PRIMARY
PUBCHEM
61745
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
PRIMARY
EPA CompTox
DTXSID9049667
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
PRIMARY
ChEMBL
CHEMBL3707298
Created by admin on Sat Dec 16 05:09:15 GMT 2023 , Edited by admin on Sat Dec 16 05:09:15 GMT 2023
PRIMARY
SUBSTANCE RECORD
Structure of MAGNESIUM PEROXIDE
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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