LAVOLTIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H29N5O2
Molecular Weight	359.4659
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1N=C(CO)N=C1NCCCOC2=CC=CC(CN3CCCCC3)=C2

InChI

InChIKey=VTLNPNNUIJHJQB-UHFFFAOYSA-N

InChI=1S/C19H29N5O2/c1-23-19(21-18(15-25)22-23)20-9-6-12-26-17-8-5-7-16(13-17)14-24-10-3-2-4-11-24/h5,7-8,13,25H,2-4,6,9-12,14-15H2,1H3,(H,20,21,22)

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6145595 | https://www.ncbi.nlm.nih.gov/pubmed/4041682 | https://www.ncbi.nlm.nih.gov/pubmed/2878860

LAVOLTIDINE, also known as loxtidine, is a highly potent and selective histamine H2-receptor antagonist. It is a member of triazoles. It produces gastric carcinoid tumors in rodents that is why its clinical development was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Global expression analysis of ECL cells in Mastomys natalensis gastric mucosa identifies alterations in the AP-1 pathway induced by gastrin-mediated transformation.	2004 Dec 15	15602048
Classification of tumours.	2008 Nov 14	19014574
The CCK(2) receptor antagonist, YF476, inhibits Mastomys ECL cell hyperplasia and gastric carcinoid tumor development.	2010 Jun 8	20144901
Long-term gastric changes in achlorhydric H(+)/K(+)-ATPase beta subunit deficient mice.	2010 Sep	20476858

Name

Type

Language

LAVOLTIDINE

Official Name

English

LOXTIDINE

Common Name

English

1H-1,2,4-TRIAZOLE-3-METHANOL, 1-METHYL-5-((3-(3-(1-PIPERIDINYLMETHYL)PHENOXY)PROPYL)AMINO)-

Systematic Name

English

Lavoltidine [WHO-DD]

Common Name

English

AH-23844 FREE BASE

Code

English

lavoltidine [INN]

Common Name

English

1-METHYL-5-((3-((.ALPHA.-PIPERIDINO-M-TOLYL)OXY)PROPYL)AMINO)-1H-1,2,4-TRIAZOLE-3-METHANOL

Systematic Name

English

LOXOTIDINE

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID0020785