VINYL CHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H3Cl
Molecular Weight	62.498
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

ClC=C

InChI

InChIKey=BZHJMEDXRYGGRV-UHFFFAOYSA-N

InChI=1S/C2H3Cl/c1-2-3/h2H,1H2

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Description

Vinyl Chloride, a gas, is produced as a combustion product in tobacco smoke. Vinyl Chloride is used to produce polyvinyl chloride (PVC) and was workers exposed to vinyl chloride were at carcinogenic risk.

Approval Year

Doses

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Dose	Population	Adverse events
2 % 1 times / day single, respiratory Studied dose	healthy, 25 to 55 years n = 6	Other AEs: Headache, Dizziness...
683 ppm multiple, respiratory (total yearly dose) Studied dose	unhealthy, 78 years n = 1	Other AEs: Hepatocellular carcinoma, Angiosarcoma...

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AEs

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AE	Dose	Population
Dizziness	2 % 1 times / day single, respiratory Studied dose	healthy, 25 to 55 years n = 6
Lightheadedness	2 % 1 times / day single, respiratory Studied dose	healthy, 25 to 55 years n = 6
Nausea	2 % 1 times / day single, respiratory Studied dose	healthy, 25 to 55 years n = 6
Visual disorders NEC	2 % 1 times / day single, respiratory Studied dose	healthy, 25 to 55 years n = 6
Worsening of auditory acuity	2 % 1 times / day single, respiratory Studied dose	healthy, 25 to 55 years n = 6

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Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
	CYP2E1 667 ALDH2 19

Drug as victim

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Target	Modality	Activity	Metabolite	Clinical evidence
ALDH2 19	substrate 3,367	yes
CYP2E1 667	substrate 3,367	yes

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Sourcing

Sourcing

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Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B4-2652	http://www.3bsc.com/index/pro_info.php?id=72877
AHH Chemical co.,ltd	MR-1001671	http://www.ahhchemical.com/product/MR-1001671.html
ChemMol	49416630	http://www.chemmol.com/chemmol/49416630.html
ChemMol	99138602	http://www.chemmol.com/chemmol/99138602.html
Clearsynth	CS-C-01096	https://www.clearsynth.com/en/CSC01096.html

Showing 1 to 5 of 21 entries

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PubMed

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Title	Date	PubMed
Liver angiosarcoma and hemangiopericytoma after occupational exposure to vinyl chloride monomer.	2000 Aug	10964802
Deficiency of N-methylpurine-DNA-glycosylase expression in nonparenchymal cells, the target cell for vinyl chloride and vinyl fluoride.	2000 Jul 25	10882851
Historical cohort study of 10 109 men in the North American vinyl chloride industry, 1942-72: update of cancer mortality to 31 December 1995.	2000 Nov	11024202
Characteristic hydrogen concentrations for various redox processes in batch study.	2001	11688686
An improved method of hydrogen production as electron donor for anaerobic bioremediation.	2001	11688682