VINYL CHLORIDE

US Previously Marketed

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H3Cl
Molecular Weight	62.498
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC=C

InChI

InChIKey=BZHJMEDXRYGGRV-UHFFFAOYSA-N

InChI=1S/C2H3Cl/c1-2-3/h2H,1H2

HIDE SMILES / InChI

Molecular Formula	C2H3Cl
Molecular Weight	62.498
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23271343 | https://www.cancer.gov/about-cancer/causes-prevention/risk/substances/vinyl-chloride

Vinyl Chloride, a gas, is produced as a combustion product in tobacco smoke. Vinyl Chloride is used to produce polyvinyl chloride (PVC) and was workers exposed to vinyl chloride were at carcinogenic risk.

Approval Year

Doses

Dose	Population	Adverse events
2 % 1 times / day single, respiratory Studied dose Dose: 2 %, 1 times / day Route: respiratory Route: single Dose: 2 %, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13929916/	healthy, 25 to 55 years Health Status: healthy Age Group: 25 to 55 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/13929916/	Other AEs: Headache, Dizziness... Other AEs: Headache (16.7%) Dizziness Nausea Visual disorders NEC Worsening of auditory acuity Lightheadedness Sources: https://pubmed.ncbi.nlm.nih.gov/13929916/
683 ppm multiple, respiratory Studied dose Dose: 683 ppm Route: respiratory Route: multiple Dose: 683 ppm Sources: https://pubmed.ncbi.nlm.nih.gov/27544804/	unhealthy, 78 years Health Status: unhealthy Age Group: 78 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/27544804/	Other AEs: Hepatocellular carcinoma, Angiosarcoma... Other AEs: Hepatocellular carcinoma Angiosarcoma Sources: https://pubmed.ncbi.nlm.nih.gov/27544804/

AEs

AE	Significance	Dose	Population
Dizziness		2 % 1 times / day single, respiratory Studied dose Dose: 2 %, 1 times / day Route: respiratory Route: single Dose: 2 %, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13929916/	healthy, 25 to 55 years Health Status: healthy Age Group: 25 to 55 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/13929916/
Lightheadedness		2 % 1 times / day single, respiratory Studied dose Dose: 2 %, 1 times / day Route: respiratory Route: single Dose: 2 %, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13929916/	healthy, 25 to 55 years Health Status: healthy Age Group: 25 to 55 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/13929916/
Nausea		2 % 1 times / day single, respiratory Studied dose Dose: 2 %, 1 times / day Route: respiratory Route: single Dose: 2 %, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13929916/	healthy, 25 to 55 years Health Status: healthy Age Group: 25 to 55 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/13929916/
Visual disorders NEC		2 % 1 times / day single, respiratory Studied dose Dose: 2 %, 1 times / day Route: respiratory Route: single Dose: 2 %, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13929916/	healthy, 25 to 55 years Health Status: healthy Age Group: 25 to 55 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/13929916/
Worsening of auditory acuity		2 % 1 times / day single, respiratory Studied dose Dose: 2 %, 1 times / day Route: respiratory Route: single Dose: 2 %, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13929916/	healthy, 25 to 55 years Health Status: healthy Age Group: 25 to 55 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/13929916/
Headache	16.7%	2 % 1 times / day single, respiratory Studied dose Dose: 2 %, 1 times / day Route: respiratory Route: single Dose: 2 %, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13929916/	healthy, 25 to 55 years Health Status: healthy Age Group: 25 to 55 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/13929916/
Angiosarcoma		683 ppm multiple, respiratory Studied dose Dose: 683 ppm Route: respiratory Route: multiple Dose: 683 ppm Sources: https://pubmed.ncbi.nlm.nih.gov/27544804/	unhealthy, 78 years Health Status: unhealthy Age Group: 78 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/27544804/
Hepatocellular carcinoma		683 ppm multiple, respiratory Studied dose Dose: 683 ppm Route: respiratory Route: multiple Dose: 683 ppm Sources: https://pubmed.ncbi.nlm.nih.gov/27544804/	unhealthy, 78 years Health Status: unhealthy Age Group: 78 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/27544804/

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
	CYP2E1 729 ALDH2 21

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
ALDH2 21	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/12739102/	yes
CYP2E1 729	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/12739102/	yes

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B4-2652	http://www.3bsc.com/index/pro_info.php?id=72877
abcr GmbH	AB333851	http://www.abcr.de/shop/en/AB333851
AHH Chemical co.,ltd	MR-1001671	http://www.ahhchemical.com/product/MR-1001671.html
ChemMol	49416630	http://www.chemmol.com/chemmol/49416630.html
ChemMol	99138602	http://www.chemmol.com/chemmol/99138602.html
Clearsynth	CS-C-01096	https://www.clearsynth.com/en/CSC01096.html
eNovation Chemicals	D628308	https://www.enovationchem.com/ProductDetails.asp?ProductID=D628308
Finetech	FT-0606106	http://www.finetechnology-ind.com/prod/detail/pub/75-35-4.html
Finetech	FT-0693147	http://www.finetechnology-ind.com/prod/detail/pub/75-01-4.html
Glentham Life Sciences	GK7035	http://www.glentham.com/products/product/GK7035/
iChemical	EBD41894	http://www.ichemical.com/chemicals/cas-75-01-4
LGC Standards	DRE-GA09010500ME	https://www.lgcstandards.com/US/en/p/DRE-GA09010500ME
LGC Standards	DRE-GA09011114ME	https://www.lgcstandards.com/US/en/p/DRE-GA09011114ME
LGC Standards	DRE-Y17923000ME	https://www.lgcstandards.com/US/en/p/DRE-Y17923000ME
mcule	MCULE-9678046268	https://mcule.com/MCULE-9678046268/
MuseChem	R070864	https://www.musechem.com/product/R070864.html
Parchem	42057	https://www.parchem.com/chemical-supplier-distributor/Vinyl-chloride-042057.aspx
Sigma-Aldrich	387622_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/387622?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	744484_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/744484?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule	S561682	https://www.smolecule.com/products/s561682
Yuhao Chemical	XJ3453	http://www.chemyuhao.com/9002-86-2.html

PubMed

Title	Date	PubMed
Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues.	2002-09	12110316
Epoxidations by peracid anions in water: ambiphilic oxenoid reactivity and stereoselectivity.	2002-08-08	12153203
Copolymerization studies of vinyl chloride and vinyl acetate with ethylene using a transition-metal catalyst.	2002-07-31	12137520
Determination of zinc (II) in pharmaceuticals based on a flow-through bulk optode.	2002-07-31	12093509
Natural attenuation of chlorinated solvents at Area 6, Dover Air Force Base: groundwater biogeochemistry.	2002-07	12143993
Natural attenuation of chlorinated solvents at Area 6, Dover Air Force Base: characterization of microbial community structure.	2002-07	12143992
Preparation of refractive index matching polymer film alternative to oil for use in a portable surface-plasmon resonance phenomenon-based chemical sensor method.	2002-07	12110971
Embryo-fetal developmental and reproductive toxicology of vinyl chloride in rats.	2002-07	12075123
Phylogenetic characterization of microbial communities that reductively dechlorinate TCE based upon a combination of molecular techniques.	2002-06-15	12099461
Dehalogenation of chlorinated ethenes and immobilization of nickel in anaerobic sediment columns under sulfidogenic conditions.	2002-06-15	12099458
Natural formation of vinyl chloride in the terrestrial environment.	2002-06-01	12075808
Microbiological, biological, and chemical weapons of warfare and terrorism.	2002-06	12074487
An increased standardised mortality ratio for liver cancer among polyvinyl chloride workers in Taiwan.	2002-06	12040117
Stable carbon isotope fractionation during enhanced in situ bioremediation of trichloroethene.	2002-05-15	12038839
Cometabolism of cis-1,2-dichloroethene by aerobic cultures grown on vinyl chloride as the primary substrate.	2002-05-15	12038826
Aqueous room temperature metal-catalyzed living radical polymerization of vinyl chloride.	2002-05-08	11982341
Renal cell carcinoma and occupational exposure to chemicals in Canada.	2002-05	12063361
XRCC1 and CYP2E1 polymorphisms as susceptibility factors of plasma mutant p53 protein and anti-p53 antibody expression in vinyl chloride monomer-exposed polyvinyl chloride workers.	2002-05	12010862
Animal models for scleroderma: an update.	2002-04	11890881
Pathology of vinyl chloride. 1970.	2002-03-20	11899947
Translating evidence about occupational conditions into strategies for prevention.	2002-03	11886955
Novel activity of Escherichia coli mismatch uracil-DNA glycosylase (Mug) excising 8-(hydroxymethyl)-3,N4-ethenocytosine, a potential product resulting from glycidaldehyde reaction.	2002-02-19	11841206
Synthesis of (chlorovinyl)cobaloxime complexes, model complexes of proposed intermediates in the B12-catalyzed dehalogenation of chlorinated ethylenes.	2002-02-07	12120381
Health risk assessment on residents exposed to chlorinated hydrocarbons contaminated in groundwater of a hazardous waste site.	2002-02	11911487
Preparation, characterization and in vitro drug release of isosorbide dinitrate microspheres.	2002-01-29	11811761
Synthesis and characterization of chlorinated alkenylcobaloximes to probe the mechanism of vitamin B(12)-catalyzed dechlorination of priority pollutants.	2002-01-28	11800630
[Vinyl chloride and chemical industry: Italian involvement in the conspiracy].	2002-01-16	11789460
[Vinyl chloride and chemical industry in the United States and in Europe: proofs of illegal conspiracy of companies].	2002-01-16	11789459
The use of reverse diffusion to validate the performance of diffusive samplers.	2002-01-05	11767931
[Clinical characteristics of early symptoms caused by chronic exposure to vinyl chloride].	2002	12061072
Volatile fatty acids as electron donors for the reductive dechlorination of chloroethenes.	2002	12046645
Flux of gases across the air-water interface studied by reversed-flow gas chromatography.	2001-11-16	11762762
[Synthesis of th IARC study on the European cohort of CVM workers. Carried out by the editors of E&P].	2001-11-08	11697177
[The environment and autoimmunity--from external causes to inner conflicts].	2001-11-01	11721304
Transition from cometabolic to growth-linked biodegradation of vinyl chloride by a Pseudomonas sp. isolated on ethene.	2001-11-01	11718337
Use of biomarkers in risk assessment.	2001-11	11759167
Urinary thiodiglycolic acid levels for vinyl chloride monomer-exposed polyvinyl chloride workers.	2001-11	11725332
Update of the follow-up of mortality and cancer incidence among European workers employed in the vinyl chloride industry.	2001-11	11679801
Oxidation of chlorinated ethenes by potassium permanganate: a kinetics study.	2001-10-12	11566407
Fentanyl-selective polymeric membrane electrode.	2001-10	11683122
Effect of solar radiation on the migration of vinyl chloride monomer from unplasticized PVC pipes.	2001-10	11547848
Atmospheric input of organic pollutants to the Venice Lagoon.	2001-09-14	11554187
Gas phase reduction of chlorinated VOCs by zero valent iron.	2001-09	11597112
Testing a multimedia compartmental model with monitoring data.	2001-09	11521843
High prevalence of K-ras-2 mutations in hepatocellular carcinomas in workers exposed to vinyl chloride.	2001-08	11563603
A simple model for the distribution and fate of organic chemicals in a landfill: MOCLA.	2001-06	11699855
[Review of significant studies on monomer vinyl chloride produced in municipal waste landfill plants].	2001	11758289
Characteristic hydrogen concentrations for various redox processes in batch study.	2001	11688686
An improved method of hydrogen production as electron donor for anaerobic bioremediation.	2001	11688682
A case of polymyositis with anti-histidyl-t-RNA synthetase (Jo-1) antibody syndrome following extensive vinyl chloride exposure.	2001	11642524

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:36:22 GMT 2025` Edited by `admin` on `Mon Mar 31 17:36:22 GMT 2025`
Record UNII	WD06X94M2D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

VINYL CHLORIDE

Official Name

English

F-1140

Preferred Name

English

CHLOROETHYLENE

Systematic Name

English

VINYL CHLORIDE [HSDB]

Common Name

English

VINYL CHLORIDE [IARC]

Common Name

English

MONOCHLOROETHYLENE

Systematic Name

English

VCM

Common Name

English

ETHYLENE CHLORIDE

Common Name

English

VINYL CHLORIDE [MI]

Common Name

English

VINYL CHLORIDE [MART.]

Common Name

English

1-CHLOROETHYLENE

Systematic Name

English

Classification Tree Code System Code

CFR

21 CFR 310.502