VINYL CHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H3Cl
Molecular Weight	62.498
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

ClC=C

InChI

InChIKey=BZHJMEDXRYGGRV-UHFFFAOYSA-N

InChI=1S/C2H3Cl/c1-2-3/h2H,1H2

HIDE SMILES / InChI

Molecular Formula	C2H3Cl
Molecular Weight	62.498
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

Vinyl Chloride, a gas, is produced as a combustion product in tobacco smoke. Vinyl Chloride is used to produce polyvinyl chloride (PVC) and was workers exposed to vinyl chloride were at carcinogenic risk.

Approval Year

Doses

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Dose	Population	Adverse events
2 % 1 times / day single, respiratory Studied dose	healthy, 25 to 55 years	Other AEs: Headache, Dizziness...
683 ppm multiple, respiratory Studied dose	unhealthy, 78 years	Other AEs: Hepatocellular carcinoma, Angiosarcoma...

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AEs

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AE	Dose	Population
Dizziness	2 % 1 times / day single, respiratory Studied dose	healthy, 25 to 55 years
Lightheadedness	2 % 1 times / day single, respiratory Studied dose	healthy, 25 to 55 years
Nausea	2 % 1 times / day single, respiratory Studied dose	healthy, 25 to 55 years
Visual disorders NEC	2 % 1 times / day single, respiratory Studied dose	healthy, 25 to 55 years
Worsening of auditory acuity	2 % 1 times / day single, respiratory Studied dose	healthy, 25 to 55 years

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Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
	CYP2E1 667 ALDH2 19

Drug as victim

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Target	Modality	Activity	Metabolite	Clinical evidence
ALDH2 19	substrate 3,367	yes
CYP2E1 667	substrate 3,367	yes

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Sourcing

Sourcing

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Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B4-2652	http://www.3bsc.com/index/pro_info.php?id=72877
abcr GmbH	AB333851	http://www.abcr.de/shop/en/AB333851
AHH Chemical co.,ltd	MR-1001671	http://www.ahhchemical.com/product/MR-1001671.html
ChemMol	49416630	http://www.chemmol.com/chemmol/49416630.html
ChemMol	99138602	http://www.chemmol.com/chemmol/99138602.html

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PubMed

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Title	Date	PubMed
Historical cohort study of 10 109 men in the North American vinyl chloride industry, 1942-72: update of cancer mortality to 31 December 1995.	2000 Nov	11024202
[Review of significant studies on monomer vinyl chloride produced in municipal waste landfill plants].	2001	11758289
Characteristic hydrogen concentrations for various redox processes in batch study.	2001	11688686
An improved method of hydrogen production as electron donor for anaerobic bioremediation.	2001	11688682
A case of polymyositis with anti-histidyl-t-RNA synthetase (Jo-1) antibody syndrome following extensive vinyl chloride exposure.	2001	11642524