U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C18H25NO.BrH.H2O
Molecular Weight 376.361
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DEUDEXTROMETHORPHAN HYDROBROMIDE

SMILES

O.Br.[H][C@]12CCCC[C@]13CCN([C@H]2CC4=CC=C(OC([2H])([2H])[2H])C=C34)C([2H])([2H])[2H]

InChI

InChIKey=STTADZBLEUMJRG-CDZAPMPLSA-N
InChI=1S/C18H25NO.BrH.H2O/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18;;/h6-7,12,15,17H,3-5,8-11H2,1-2H3;1H;1H2/t15-,17+,18+;;/m1../s1/i1D3,2D3;;

HIDE SMILES / InChI
Dextromethorphan D6 is a weak uncompetitive antagonist of the NMDA receptor. Dextromethorphan is also acts at nicotinic receptors, sigma-1 rcptor and serotonin and norepinephrine transporters. The incorporation of deuterium serves to reduce dextromethorphan first-pass liver metabolism. AVP-786 is an oral formulation of a combination of deuterated (d6)-dextromethorphan and an ultra-low dose of quinidine. Avanir Pharmaceuticals launched a phase III development program of AVP-786 for the treatment of agitation in patients with Alzheimer's disease.

Approval Year

Name Type Language
DEUDEXTROMETHORPHAN HYDROBROMIDE
USAN  
USAN  
Official Name English
AVP-786 COMPONENT DEUDEXTROMETHORPHAN HYDROBROMIDE
Code English
DEUDEXTROMETHORPHAN HYDROBROMIDE [USAN]
Common Name English
3-[(2H3)Methoxy]-17-[(2H3)methyl]-ent-morphinan hydrobromide monohydrate
Systematic Name English
MORPHINAN, 3-(METHOXY-D3)-17-(METHYL-D3)-, (9.ALPHA.,13.ALPHA.,14.ALPHA.)-HYDROBROMIDE MONOHYDRATE
Common Name English
DEUDEXTROMETHORPHAN HYDROBROMIDE MONOHYDRATE
Common Name English
DEUDEXTROMETHORPHAN HYDROBROMIDE COMPONENT OF AVP-786
Code English
DEXTROMETHORPHAN D6 HYDROBROMIDE MONOHYDRATE
Common Name English
D6-DM HYDROBROMIDE MONOHYDRATE
Common Name English
Code System Code Type Description
RXCUI
2569465
Created by admin on Sat Dec 16 09:32:09 GMT 2023 , Edited by admin on Sat Dec 16 09:32:09 GMT 2023
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NCI_THESAURUS
C169891
Created by admin on Sat Dec 16 09:32:09 GMT 2023 , Edited by admin on Sat Dec 16 09:32:09 GMT 2023
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SMS_ID
300000040301
Created by admin on Sat Dec 16 09:32:09 GMT 2023 , Edited by admin on Sat Dec 16 09:32:09 GMT 2023
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USAN
DE-128
Created by admin on Sat Dec 16 09:32:09 GMT 2023 , Edited by admin on Sat Dec 16 09:32:09 GMT 2023
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PUBCHEM
90479359
Created by admin on Sat Dec 16 09:32:09 GMT 2023 , Edited by admin on Sat Dec 16 09:32:09 GMT 2023
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CAS
1373497-18-7
Created by admin on Sat Dec 16 09:32:09 GMT 2023 , Edited by admin on Sat Dec 16 09:32:09 GMT 2023
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FDA UNII
W9F1OD5N5J
Created by admin on Sat Dec 16 09:32:09 GMT 2023 , Edited by admin on Sat Dec 16 09:32:09 GMT 2023
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DAILYMED
W9F1OD5N5J
Created by admin on Sat Dec 16 09:32:09 GMT 2023 , Edited by admin on Sat Dec 16 09:32:09 GMT 2023
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