Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C21H34N2O.ClH |
| Molecular Weight | 366.968 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCCCCCN1CCC(CC1)(C(=O)N(C)CC)C2=CC=CC=C2
InChI
InChIKey=VFXXNIHMKMOIQN-UHFFFAOYSA-N
InChI=1S/C21H34N2O.ClH/c1-4-6-7-11-16-23-17-14-21(15-18-23,20(24)22(3)5-2)19-12-9-8-10-13-19;/h8-10,12-13H,4-7,11,14-18H2,1-3H3;1H
Sameridine was developed as a compound with both local anesthetic and opioid properties (partial micro-opioid receptor agonist). This drug participated in clinical trials when administered intrathecally to provide anesthesia for surgery and extended postoperative analgesia. However, further development of this drug was discontinued.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Hypercarbic and hypoxic ventilatory responses after intrathecal administration of bupivacaine and sameridine. | 2003-02 |
|
| Novel local anaesthetics and novel indications for local anaesthetics. | 2001-12 |
|
| Determination of sameridine in blood plasma by nitrogen-selective gas chromatography. | 2001-08-25 |
|
| The effects on hypercarbic ventilatory response of sameridine compared to morphine and placebo. | 2001-02 |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
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Common Name | English | ||
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Preferred Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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V3TSQ43P49
Created by
admin on Wed Apr 02 01:11:32 GMT 2025 , Edited by admin on Wed Apr 02 01:11:32 GMT 2025
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9842135
Created by
admin on Wed Apr 02 01:11:32 GMT 2025 , Edited by admin on Wed Apr 02 01:11:32 GMT 2025
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136483-84-6
Created by
admin on Wed Apr 02 01:11:32 GMT 2025 , Edited by admin on Wed Apr 02 01:11:32 GMT 2025
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PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD
