MANNOMUSTINE HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H22Cl2N2O4.2ClH
Molecular Weight	378.121
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.Cl.O[C@H](CNCCCl)[C@@H](O)[C@H](O)[C@H](O)CNCCCl

InChI

InChIKey=GBKLAYXZNQSPBS-XYSQQLOGSA-N

InChI=1S/C10H22Cl2N2O4.2ClH/c11-1-3-13-5-7(15)9(17)10(18)8(16)6-14-4-2-12;;/h7-10,13-18H,1-6H2;2*1H/t7-,8-,9-,10-;;/m1../s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13671231 | https://www.ncbi.nlm.nih.gov/pubmed/13910448 | https://link.springer.com/book/10.1007/978-1-4757-2085-3#about | https://www.drugfuture.com/chemdata/mannomustine.html

Mannomustine is a substance synthesized as one of a series of compounds linking the actively cytotoxic chemical group beta-chlorethylamine with a naturally occurring substance, mannitol. Mannomustine is an alkylating agent with antineoplastic properties. It was being studied in the treatment of hematologic malignancies.

Originator

Approval Year

PubMed

Title	Date	PubMed
Mannomustine in treatment of leukaemias, polycythaemia, and malignant disorders.	1959 Aug 22	13671231
Clinical results after 5 years of treatment of tumours and leukaemias with degranol (Mannomustine).	1961 Oct	13910448
Mannomustine (dihydrochloride).	1975	791830

Sample Use Guides

In Vivo Use Guide

the maximal single dose is 100 mg daily or on alternate days

Route of Administration: Other

Name

Type

Language

MANNOMUSTINE HYDROCHLORIDE

Common Name

English

MANNITOL MUSTARD DIHYDROCHLORIDE

Common Name

English

1,6-BIS(.BETA.-CHLORETHYLAMINO)-1,6-DIDESOXY-D-MANNITOL DIHYDROCHLORIDE

Systematic Name

English

MANNITOL, 1,6-BIS((2-CHLOROETHYL)AMINO)-1,6-DIDEOXY-, DIHYDROCHLORIDE, D-

Systematic Name

English

NSC-9698 HYDROCHLORIDE

Code

English

D-MANNITOL, 1,6-BIS((2-CHLOROETHYL)AMINO)-1,6-DIDEOXY-, DIHYDROCHLORIDE

Systematic Name

English

MANNOMUSTINE DIHYDROCHLORIDE [IARC]

Common Name

English

MANNOMUSTINE [MI]

Common Name

English

MANNOMUSTINE DIHYDROCHLORIDE

Common Name

English

DEGRANOL CHINOIN

Common Name

English

NSC-9698

Code

English

Code System Code Type Description

EPA CompTox

DTXSID40970470