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Details

Stereochemistry ABSOLUTE
Molecular Formula C12H22O11.Fe.3HO
Molecular Weight 449.164
Optical Activity UNSPECIFIED
Defined Stereocenters 9 / 9
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IRON POLYMALTOSE

SMILES

[OH-].[OH-].[OH-].[Fe+3].OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

InChIKey=PKMVWNYIYVZXIQ-MPAYLTKRSA-K
InChI=1S/C12H22O11.Fe.3H2O/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12;;;;/h1,4-12,14-21H,2-3H2;;3*1H2/q;+3;;;/p-3/t4-,5+,6+,7+,8+,9+,10-,11+,12-;;;;/m0..../s1

HIDE SMILES / InChI

Description
Sources: http://www.mfc.co.jp/english/eng/product/sanferol/pdf/fls_gras_notice.pdfhttps://mistralhowto.wordpress.com/2012/03/12/what-is-pigment-yellow-42-and-what-is-it-used-for/ | http://sensientfoodcolors.com/en-us/confection/iron-oxides-approved-by-the-fda/ | https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=73.2250 | https://www.drugs.com/inactive/ferric-oxide-yellow-381.htmlhttps://books.google.ru/books?id=vxtxWneRBN4C&pg=PA1103&#v=onepage&q&f=falsehttps://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205874Orig1s000PharmR.pdfhttp://www.edta-chelate.com/ferric-ammonium-edta-liquid--1640836.htmlhttps://books.google.ru/books?id=3hLmyma2-MsC&pg=PA241&lpg=PA241&dq=FERRIC+AMMONIUM+CHLORIDE retrieved from A Consumer's Dictionary of Cosmetic Ingredients, 7th Edition: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics and Cosmeceuticals By Ruth Winterhttps://www.ncbi.nlm.nih.gov/pubmed/27995746 | http://onlinelibrary.wiley.com/doi/10.1002/047084289X.rn01568/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=https://cameochemicals.noaa.gov/chemical/3468 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.ncbi.nlm.nih.gov/pubmed/27684194 | https://www.ncbi.nlm.nih.gov/pubmed/17511797 | https://www.ncbi.nlm.nih.gov/pubmed/1427505
Curator's Comment: description was created based on several sources, including https://www.gpo.gov/fdsys/pkg/CFR-1996-title21-vol3/pdf/CFR-1996-title21-vol3-sec182-5375.pdf

Ferric chloride is a compound used as a food additive, a haemostatic or treatment for hypochromic anaemia. Ferric chloride induced vascular injury is a widely used model of occlusive thrombosis that reports platelet activation and aggregation in the context of an aseptic closed vascular system. Iron i.v. ferric chloride (960 mg) has being shown to be effective in correcting anaemia in HD patients with iron deficiency.

Originator

Monsanto Chemicals
44
Curator's Comment: The relation between phosphate level and ferric citrate consumption was first discovered in 1940s.

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1430
Chelating Agent
142
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Additrace N

Approved Use

A source of electrolytes and trace elements as an integral part of a complete intravenous nutritional regimen, for adults and children over 40 kg.
Preventing
Approved
8429
Parmirin

Approved Use

Preventive treatment of iron deficiency
Primary
Basic research
Unknown

Approved Use

Unknown
Primary
Approved
8429
SANFEROL

Approved Use

It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Inactive ingredient
Approved
8429
Oxycontin

Approved Use

OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

1998
Curative
Approved
8429
RADIOGARDASE

Approved Use

Insoluble Prussian blue is indicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase their rates of elimination.

Launch Date

2003
Palliative
Approved
8429
AURYXIA

Approved Use

Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.

Launch Date

2014
PubMed

PubMed

TitleDatePubMed
The formation of ferritin from apoferritin. Kinetics and mechanism of iron uptake.
1972 Jan
Metal-mediated cyclization of aryl and benzyl glycidyl ethers: a complete scenario.
2008 Dec 17
Fabrication of FeF3 Nanoflowers on CNT branches and their application to high power lithium rechargeable batteries.
2010 Dec 7
Heme Binding by Corynebacterium diphtheriae HmuT: Function and Heme Environment.
2015 Nov 3
Halide Influence on Molecular and Supramolecular Arrangements of Iron Complexes with a 3,5-Bis(2-Pyridyl)-1,2,4,6-Thiatriazine Ligand.
2016 Jun 6
Patents

Patents

20080188032
44
20090216060
44
6258758
44
US 5206265 A
44
US2385188
44
US3873678
44
US4364871
44
US6881255
44
US6903235
44
US7198668
44
US8071067
44

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Iron oxides black, red and yellow are intended to be used as colourants in feedingstuffs for all animal species without dose or age restriction. The applicant recommends 500–1,200 mg/kg of the additives in complete (and complementary) feedingstuffs as standard dose. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4482/full
Ferric sodium citrate is an additive used in various foods such as baby milk powder, school and hospital food, beverages, cereals and supplements. It is administered orally.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
IRON POLYMALTOSE
Common Name English
FERROMALTOSE
Common Name English
TEFERROL
Brand Name English
Ferric hydroxide polymaltose complex [WHO-DD]
Common Name English
AMYLOFER
Brand Name English
FERRIC HYDROXIDE POLYMALTOSE COMPLEX
WHO-DD  
Common Name English
IRON(III)-HYDROXIDE POLYMALTOSE COMPLEX
Common Name English
FERRIPEL 3
Brand Name English
MALTOFER
Brand Name English
FERRUMMATE
Brand Name English
Classification Tree Code System Code
WHO-ATC B03AB05
Created by admin on Sat Dec 16 00:03:08 GMT 2023 , Edited by admin on Sat Dec 16 00:03:08 GMT 2023
Code System Code Type Description
DAILYMED
UM5219H89V
Created by admin on Sat Dec 16 00:03:08 GMT 2023 , Edited by admin on Sat Dec 16 00:03:08 GMT 2023
PRIMARY
EVMPD
SUB13845MIG
Created by admin on Sat Dec 16 00:03:08 GMT 2023 , Edited by admin on Sat Dec 16 00:03:08 GMT 2023
PRIMARY
PUBCHEM
76960246
Created by admin on Sat Dec 16 00:03:08 GMT 2023 , Edited by admin on Sat Dec 16 00:03:08 GMT 2023
PRIMARY
CAS
53858-86-9
Created by admin on Sat Dec 16 00:03:08 GMT 2023 , Edited by admin on Sat Dec 16 00:03:08 GMT 2023
PRIMARY
RXCUI
37744
Created by admin on Sat Dec 16 00:03:08 GMT 2023 , Edited by admin on Sat Dec 16 00:03:08 GMT 2023
PRIMARY RxNorm
SMS_ID
100000078919
Created by admin on Sat Dec 16 00:03:08 GMT 2023 , Edited by admin on Sat Dec 16 00:03:08 GMT 2023
PRIMARY
FDA UNII
UM5219H89V
Created by admin on Sat Dec 16 00:03:08 GMT 2023 , Edited by admin on Sat Dec 16 00:03:08 GMT 2023
PRIMARY
EPA CompTox
DTXSID101027608
Created by admin on Sat Dec 16 00:03:08 GMT 2023 , Edited by admin on Sat Dec 16 00:03:08 GMT 2023
PRIMARY
MESH
C013276
Created by admin on Sat Dec 16 00:03:08 GMT 2023 , Edited by admin on Sat Dec 16 00:03:08 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of FERRIC CATION
SUBSTANCE RECORD
Structure of IRON POLYMALTOSE
NIH
NCATS
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