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Details

Stereochemistry ACHIRAL
Molecular Formula C19H42N.Cl
Molecular Weight 319.996
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CETRIMONIUM CHLORIDE

SMILES

[Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C

InChI

InChIKey=WOWHHFRSBJGXCM-UHFFFAOYSA-M
InChI=1S/C19H42N.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(2,3)4;/h5-19H2,1-4H3;1H/q+1;/p-1

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including http://www.americanpharmaceuticalreview.com/Featured-Articles/38886-Antimicrobial-Preservatives-Part-One-Choosing-a-Preservative-System/ | https://books.google.ru/books?id=EMrSBwAAQBAJ&printsec=frontcover&hl=ru#v=onepage&q&f=false | https://www.ncbi.nlm.nih.gov/pubmed/9880479 | http://www.medindia.net/doctors/drug_information/cetrimide.htm

Cetrimide is a quaternary ammonium compound. Cetrimide was first introduced as a combined cleanser and skin antiseptic by Barnes (1942). Cetrimide combines excellent detergent properties and minimal toxicity with a useful antiseptic action. Cetrimide affects membrane permeability allowing ‘leaking’ of essential cell constituents leading to cell death. This medication is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing. The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants.

Originator

Imperial Chemical Industries
59
Curator's Comment: Cetrimide was first introduced as a combined cleanser and skin antiseptic by Barnes (1942). http://www.sciencedirect.com/science/article/pii/S0140673600701000 reference retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18132350

Approval Year

1999
174
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Interacts
323
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8429
CETRIMIDE

Approved Use

Cetrimide is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing. The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants.
Primary
Approved
8429
CETRIMIDE

Approved Use

Cetrimide is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing. The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants.
PubMed

PubMed

TitleDatePubMed
Patents

Patents

US6187290B1
9
US6284289B1
9

Sample Use Guides

In Vivo Use Guide
Wound cleansing - Topical : Adult: Apply 0.1-1% aqueous solution or 0.5% cream onto affected area. Seborrhoeic dermatitis - Topical : Adult: Apply 10% shampoo solution onto the scalp.
Route of Administration: Topical
In Vitro Use Guide
Cetrimide, at 30 ug/ml inhibited growth of Aspergillus niger.
Name Type Language
CETRIMONIUM CHLORIDE
II   INCI   MART.   WHO-DD  
INCI  
Official Name English
HEXADECYLTRIMETHYLAMMONIUM CHLORIDE
Systematic Name English
NIKKOL CA-2350
Brand Name English
PALMITYLTRIMETHYLAMMONIUM CHLORIDE
Systematic Name English
CETRIMONIUM CHLORIDE [INCI]
Common Name English
CETYLTRIMETHYLAMMONIUM CHLORIDE
Systematic Name English
N-HEXADECYLTRIMETHYLAMMONIUM CHLORIDE
Systematic Name English
JEEQUAT CT-29
Brand Name English
CETYL TRIMETHYL AMMONIUM CHLORIDE
Systematic Name English
CETYLTRIMETHYL AMMONIUM CHLORIDE
Systematic Name English
N,N,N-TRIMETHYL-1-HEXADECANAMINIUM CHLORIDE
Systematic Name English
TRIMETHYLHEXADECYLAMMONIUM CHLORIDE
HSDB  
Systematic Name English
VARISOFT 300
Brand Name English
ARQUAD PC 16-29W
Brand Name English
GENAMIN CTAC
Brand Name English
CETRIMONIUM CHLORIDE [II]
Common Name English
CETRIMONIUM CHLORIDE [MART.]
Common Name English
Cetrimonium chloride [WHO-DD]
Common Name English
TRIMETHYLHEXADECYLAMMONIUM CHLORIDE [HSDB]
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 69133
Created by admin on Fri Dec 15 15:23:53 GMT 2023 , Edited by admin on Fri Dec 15 15:23:53 GMT 2023
NCI_THESAURUS C28394
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Code System Code Type Description
MESH
C004322
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PRIMARY
EPA CompTox
DTXSID6026901
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PRIMARY
RXCUI
1311525
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PRIMARY RxNorm
CAS
112-02-7
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PRIMARY
HSDB
5553
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PRIMARY
CHEBI
53581
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PRIMARY
NCI_THESAURUS
C83614
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PRIMARY
DRUG BANK
DBSALT001770
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PRIMARY
FDA UNII
UC9PE95IBP
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PRIMARY
ECHA (EC/EINECS)
203-928-6
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PRIMARY
PUBCHEM
8154
Created by admin on Fri Dec 15 15:23:53 GMT 2023 , Edited by admin on Fri Dec 15 15:23:53 GMT 2023
PRIMARY
WIKIPEDIA
CETRIMONIUM CHLORIDE
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PRIMARY
EVMPD
SUB13302MIG
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PRIMARY
DAILYMED
UC9PE95IBP
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PRIMARY
SMS_ID
100000076344
Created by admin on Fri Dec 15 15:23:53 GMT 2023 , Edited by admin on Fri Dec 15 15:23:53 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of CETRIMONIUM
SUBSTANCE RECORD
Structure of CETRIMONIUM CHLORIDE
NIH
NCATS
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DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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