Details
Stereochemistry | ACHIRAL |
Molecular Formula | C25H27N2O5S.Na |
Molecular Weight | 490.547 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].CC(C)(C)C1=CC=C(CN(CC2=CC(OCC([O-])=O)=CC=C2)S(=O)(=O)C3=CN=CC=C3)C=C1
InChI
InChIKey=SVNBMCJEDANCKY-UHFFFAOYSA-M
InChI=1S/C25H28N2O5S.Na/c1-25(2,3)21-11-9-19(10-12-21)16-27(33(30,31)23-8-5-13-26-15-23)17-20-6-4-7-22(14-20)32-18-24(28)29;/h4-15H,16-18H2,1-3H3,(H,28,29);/q;+1/p-1
Evatanepag (CP-533,536) is a prostaglandin E2 EP2 receptor agonist. It stimulates new bone formation on trabecular, endocortical, and periosteal surfaces and enhances fracture healing. Evatanepag was under development with Pfizer as a bone formation stimulant for therapeutic use in the healing of fractures.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL1881 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24279689 |
5.0 nM [EC50] |
PubMed
Title | Date | PubMed |
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In vitro pharmacological characterization of CJ-042794, a novel, potent, and selective prostaglandin EP(4) receptor antagonist. | 2008 Jan 16 |
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CYP2C8- and CYP3A-mediated C-demethylation of (3-{[(4-tert-butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (CP-533,536), an EP2 receptor-selective prostaglandin E2 agonist: characterization of metabolites by high-resolution liquid chromatography-tandem mass spectrometry and liquid chromatography/mass spectrometry-nuclear magnetic resonance. | 2008 Oct |
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Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation. | 2009 Apr 1 |
Patents
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C78568
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300000044595
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223490-49-1
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DBSALT002124
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C83708
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DTXSID40945002
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CHEMBL563646
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U6GMO13KCQ
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UU-104
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ACTIVE MOIETY
SUBSTANCE RECORD