PROXORPHAN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H25NO2
Molecular Weight	299.4073
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=CC=C2C[C@@H]3[C@@H]4CCOC[C@]4(CCN3CC5CC5)C2=C1

InChI

InChIKey=USEITRSTDJBLBU-UHOSZYNNSA-N

InChI=1S/C19H25NO2/c21-15-4-3-14-9-18-16-5-8-22-12-19(16,17(14)10-15)6-7-20(18)11-13-1-2-13/h3-4,10,13,16,18,21H,1-2,5-9,11-12H2/t16-,18+,19-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6137557 | https://www.ncbi.nlm.nih.gov/pubmed/8394915 | https://www.ncbi.nlm.nih.gov/pubmed/2566680 | https://www.ncbi.nlm.nih.gov/pubmed/1331411

Proxorphan is a N-substituted 6-oxamorphinane patented by American pharmaceutical company Bristol-Myers Co. as opioid analgesic and antitussive drug. Proxorphan acts as a κ-opioid receptor partial agonist and to a lesser extent as a μ-opioid receptor partial agonist.

Originator

Approval Year

PubMed

Title	Date	PubMed
Discriminative stimulus effects of mu and kappa opioids in the pigeon: analysis of the effects of full and partial mu and kappa agonists.	1989-05	2566680

Patents

Name

Type

Language

(-)-(4AR,5R,10BS)-13-(CYCLOPROPYLMETHYL)-4,4A,5,6-TETRAHYDRO-3H-5,10B-(IMINOETHANO)-1H-NAPHTHO(1,2-C)-PYRAN-9-OL

Preferred Name

English

PROXORPHAN

Official Name

English

6-OXAMORPHINAN-3-OL, 17-(CYCLOPROPYLMETHYL)-

Systematic Name

English

proxorphan [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1506