Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H20N2O2 |
| Molecular Weight | 272.3422 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN(C)C(=O)OC1=CC2=C(CC[C@H]2NCC#C)C=C1
InChI
InChIKey=LHXOCOHMBFOVJS-OAHLLOKOSA-N
InChI=1S/C16H20N2O2/c1-4-10-17-15-9-7-12-6-8-13(11-14(12)15)20-16(19)18(3)5-2/h1,6,8,11,15,17H,5,7,9-10H2,2-3H3/t15-/m1/s1
LADOSTIGIL, a rasagiline derivative, is a reversible acetylcholinesterase and butyrylcholinesterase inhibitor with neuroprotective properties. It also acts as an irreversible brain monoamine oxidases inhibitor. It is under development for the treatment of neurodegenerative disorders like dementia and Alzheimer's disease.
CNS Activity
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases. | 2005 Feb |
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| Ladostigil, a novel multifunctional drug for the treatment of dementia co-morbid with depression. | 2006 |
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| The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and m30. | 2006 Dec |
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| A multifunctional, neuroprotective drug, ladostigil (TV3326), regulates holo-APP translation and processing. | 2006 Oct |
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| The application of proteomics and genomics to the study of age-related neurodegeneration and neuroprotection. | 2007 Feb |
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| Ladostigil prevents gliosis, oxidative-nitrative stress and memory deficits induced by intracerebroventricular injection of streptozotocin in rats. | 2007 Mar |
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| The New Inhibitor of Monoamine Oxidase, M30, has a Neuroprotective Effect Against Dexamethasone-Induced Brain Cell Apoptosis. | 2010 |
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| Why do we need multifunctional neuroprotective and neurorestorative drugs for Parkinson's and Alzheimer's diseases as disease modifying agents. | 2010 Jun |
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C667
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C47792
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8353
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
