Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C13H9F3N2O2 |
| Molecular Weight | 282.218 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=CN=CC=C1NC2=CC(=CC=C2)C(F)(F)F
InChI
InChIKey=NLBIKXOJCISNQP-UHFFFAOYSA-N
InChI=1S/C13H9F3N2O2/c14-13(15,16)8-2-1-3-9(6-8)18-11-4-5-17-7-10(11)12(19)20/h1-7H,(H,17,18)(H,19,20)
Triflocin is a nicotinic acid derivative. Triflocin is a diuretic agent. It is structurally dissimilar from ethacrynic acid and furosemide although their natriuretic potency and site of action in the kidney appear similar. Triflocin inhibits sodium-stimulated, ouabain-insensitive ATPase. In vivo, a natriuretic effect of Triflocin has been reported in both the proximal convoluted tubule and the thick ascending limb of Henle's loop. Upon acute isohydric hypercapnia, Triflocin depolarizes the basolateral membrane potential. Triflocin inhibits the basolateral electrogenic Na-(HCO3)n > 1 cotransport in proximal tubules.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The effect of a new diuretic, triflocin (4-(alpha,alpha,alpha-trifluoro-m-toluidino)-nicotinic acid) on blood glucose in the rat and dog. | 1969 Sep |
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| Ouabain-uninhibited Na+ Transport in human erythrocytes: the effects of triflocin. | 1972 Feb 11 |
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| Effects of triflocin on renal tubular reabsorption and blood flow distribution. | 1972 Jul |
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| The effect of triflocin, a new diuretic drug, on the renal concentrating mechanism. | 1972 Oct-Dec |
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| Micropuncture study of the effect of triflocin on tubular reabsorption in rats. | 1973 Feb |
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| Interference with feedback control of glomerular filtration rate by furosemide, triflocin, and cyanide. | 1974 Jun |
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| Partial characterization of the ouabain-insensitive, Na+-stimulated ATPase activity of kidney basal-lateral plasma membranes. | 1982 Oct 22 |
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| Effect of locally applied drugs on the pH of luminal fluid in the endolymphatic sac of guinea pig. | 2000 Nov |
Patents
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NCI_THESAURUS |
C448
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13422-16-7
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S01B3A38SK
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25969
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2827
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C76648
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C047090
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SUB11284MIG
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100000077742
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CHEMBL2104493
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
