TRIFLOCIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H9F3N2O2
Molecular Weight	282.218
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)C1=C(NC2=CC(=CC=C2)C(F)(F)F)C=CN=C1

InChI

InChIKey=NLBIKXOJCISNQP-UHFFFAOYSA-N

InChI=1S/C13H9F3N2O2/c14-13(15,16)8-2-1-3-9(6-8)18-11-4-5-17-7-10(11)12(19)20/h1-7H,(H,17,18)(H,19,20)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5057934 | https://www.ncbi.nlm.nih.gov/pubmed/5039079 | https://www.ncbi.nlm.nih.gov/pubmed/8075865

Triflocin is a nicotinic acid derivative. Triflocin is a diuretic agent. It is structurally dissimilar from ethacrynic acid and furosemide although their natriuretic potency and site of action in the kidney appear similar. Triflocin inhibits sodium-stimulated, ouabain-insensitive ATPase. In vivo, a natriuretic effect of Triflocin has been reported in both the proximal convoluted tubule and the thick ascending limb of Henle's loop. Upon acute isohydric hypercapnia, Triflocin depolarizes the basolateral membrane potential. Triflocin inhibits the basolateral electrogenic Na-(HCO3)n > 1 cotransport in proximal tubules.

Approval Year

PubMed

Title	Date	PubMed
Effect of locally applied drugs on the pH of luminal fluid in the endolymphatic sac of guinea pig.	2000-11	11049851
Triflocin, a novel inhibitor for the Na-HCO3 symport in the proximal tubule.	1994-06	8075865
Characterization and localization of ouabain-insensitive Na-dependent ATPase activities along the rat nephron.	1991-05-07	1645198
Ouabain insensitive Na+-stimulated ATPase activity associated to basal-lateral plasma membranes of rat kidney cells.	1983	6152710
Partial characterization of the ouabain-insensitive, Na+-stimulated ATPase activity of kidney basal-lateral plasma membranes.	1982-10-22	6128997
Interference with feedback control of glomerular filtration rate by furosemide, triflocin, and cyanide.	1974-06	4830232
Micropuncture study of the effect of triflocin on tubular reabsorption in rats.	1973-02	4688182
The effect of triflocin, a new diuretic drug, on the renal concentrating mechanism.	1972-10-01	4658743
Effects of triflocin on renal tubular reabsorption and blood flow distribution.	1972-07	5039079
Ouabain-uninhibited Na+ Transport in human erythrocytes: the effects of triflocin.	1972-02-11	5057934
Renal mechanisms of the natriuretic and antiphosphaturic effects of triflocin--a new diuretic.	1970-08	5434007
The effect of a new diuretic, triflocin (4-(alpha,alpha,alpha-trifluoro-m-toluidino)-nicotinic acid) on blood glucose in the rat and dog.	1969-09	5811985

Patents

Name

Type

Language

TRIFLOCIN

Official Name

English

CL 65,562

Preferred Name

English

triflocin [INN]

Common Name

English

CL-65562

Code

English

TRIFLOCIN [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C448