MERALLURIDE ACID

US Previously Marketed

First approved in 1943

Details

Stereochemistry	RACEMIC
Molecular Formula	C9H15HgN2O5.C7H8N4O2.HO
Molecular Weight	628.99
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[OH-].CN1C2=C(N=CN2)C(=O)N(C)C1=O.COC(C[Hg+])CNC(=O)NC(=O)CCC(O)=O

InChI

InChIKey=JESFLKNCDDOHQY-UHFFFAOYSA-M

InChI=1S/C9H15N2O5.C7H8N4O2.Hg.H2O/c1-6(16-2)5-10-9(15)11-7(12)3-4-8(13)14;1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;;/h6H,1,3-5H2,2H3,(H,13,14)(H2,10,11,12,15);3H,1-2H3,(H,8,9);;1H2/q;;+1;/p-1

HIDE SMILES / InChI

Description
Sources: https://www.drugfuture.com/chemdata/meralluride.html | https://www.ncbi.nlm.nih.gov/pubmed/14215515

MERALLURIDE ACID is an organomercuric compound. It was used as a diuretic in a 1:1 mixture with theophylline.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Edema 22 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13706413 https://www.ncbi.nlm.nih.gov/pubmed/14215515 https://www.ncbi.nlm.nih.gov/pubmed/5264344	Primary		Approved 8429	Mercuhydrin Approved Use Meralluride (mercuhydrin®) is an organomercuric compound. It has been used as a diuretic.

Doses

Dose	Population	Adverse events
2 mL 1 times / 2 days multiple, intramuscular Dose: 2 mL, 1 times / 2 days Route: intramuscular Route: multiple Dose: 2 mL, 1 times / 2 days Sources: https://pubmed.ncbi.nlm.nih.gov/5958596	unhealthy n = 11 Health Status: unhealthy Condition: cirrhosis Sex: M+F Population Size: 11 Sources: https://pubmed.ncbi.nlm.nih.gov/5958596	Disc. AE: Encephalopathy... AEs leading to discontinuation/dose reduction: Encephalopathy (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/5958596

AEs

AE	Significance	Dose	Population
Encephalopathy	1 patient Disc. AE	2 mL 1 times / 2 days multiple, intramuscular Dose: 2 mL, 1 times / 2 days Route: intramuscular Route: multiple Dose: 2 mL, 1 times / 2 days Sources: https://pubmed.ncbi.nlm.nih.gov/5958596	unhealthy n = 11 Health Status: unhealthy Condition: cirrhosis Sex: M+F Population Size: 11 Sources: https://pubmed.ncbi.nlm.nih.gov/5958596

Sourcing

Vendor/Aggregator	ID	URL
ChemIDplus	769856679	https://chem.nlm.nih.gov/chemidplus/id/0769856679
PubChem	122129928	https://pubchem.ncbi.nlm.nih.gov/compound/122129928
Wikidata	Q27287596

PubMed

Title	Date	PubMed
Comparison of hydroflumethiazide and meralluride. New method for quantitative assay of diuretics in bedfast patients with edema.	1961 Jul 29	13706413
DIURETIC EFFECT OF POLYTHIAZIDE AND SODIUM MERALLURIDE. COMPARISON IN BEDFAST PATIENTS WITH EDEMA.	1964 Nov 16	14215515
Relative diuretic potential of intramuscular meralluride and oral hydrochlorothiazide in patients with edema.	1970 Mar-Apr	5264344

Name

Type

Language

MERALLURIDE ACID

Common Name

English

1:1 MIXTURE OF N-((3-(HYDROXYMERCURI)-2-METHOXYPROPYL)CARBAMOYL)SUCCINAMIC ACID AND THEOPHYLLINE

Common Name

English

Meralluride [WHO-DD]

Common Name

English

Code System Code Type Description

WIKIPEDIA

MERALLURIDE