U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C25H35NO4
Molecular Weight 413.5497
Optical Activity UNSPECIFIED
Defined Stereocenters 7 / 7
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIHYDROETORPHINE

SMILES

[H][C@@]12OC3=C(O)C=CC4=C3[C@@]15CCN(C)[C@]([H])(C4)[C@]56CC[C@@]2(OC)[C@]([H])(C6)[C@](C)(O)CCC

InChI

InChIKey=BRTSNYPDACNMIP-FAWZKKEFSA-N
InChI=1S/C25H35NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,17-18,21,27-28H,5,8-14H2,1-4H3/t17-,18-,21-,22-,23-,24+,25-/m1/s1

HIDE SMILES / InChI

Approval Year

PubMed

PubMed

TitleDatePubMed
Pharmacokinetic and pharmacodynamic evaluations of a potent analgesic, dihydroetorphine, in hairless rat.
2001 Feb
A protective effect against undesirable increase of dihydroetorphine permeation through damaged skin by using pressure-sensitive adhesive tape with an ethylene-vinyl acetate co-polymer membrane.
2001 Jan
Tolerance to analgesia and dependence liability by topical application of dihydroetorphine to hairless rats.
2001 Jul 6
Biochemical characterisation of newly developed beta-etorphine and beta-dihydroetorphine derivatives.
2002 May 3
Discriminative stimulus and antinociceptive effects of dihydroetorphine in rhesus monkeys.
2003 Apr
Binding affinity to and dependence on some opioids in Sf9 insect cells expressing human mu-opioid receptor.
2003 Sep
The orvinols and related opioids--high affinity ligands with diverse efficacy profiles.
2004
Tramadol and dihydroetorphine produce synergistic analgesic effect and postpones acute opiate tolerance in rats.
2005 Dec 25
Paradoxical relationship between RAVE (relative activity versus endocytosis) values of several opioid receptor agonists and their liability to cause dependence.
2010 Apr
Name Type Language
DIHYDROETORPHINE
WHO-DD  
Common Name English
TETRAHYDRO-7.ALPHA.-(1-HYDROXY-1-METHYLBUTYL)-6,14-ENDO-ETHANOORIPAVINE
Common Name English
Dihydroetorphine [WHO-DD]
Common Name English
IDS-ND-025
Code English
6,14-ETHENOMORPHINAN-7-METHANOL, 4,5-EPOXY-18,19-DIHYDRO-3-HYDROXY-6-METHOXY-.ALPHA.,17-DIMETHYL-.ALPHA.-PROPYL-, (.ALPHA.R,5.ALPHA.,7.ALPHA.)
Common Name English
7,8-DIHYDRO-7.ALPHA.-(1-(R)-HYDROXY-1-METHYLBUTYL)-6,14-ENDOETHANOTETRAHYDROORIPAVINE
Systematic Name English
Classification Tree Code System Code
DEA NO. 9334
Created by admin on Sat Dec 16 10:31:24 GMT 2023 , Edited by admin on Sat Dec 16 10:31:24 GMT 2023
Code System Code Type Description
PUBCHEM
107765
Created by admin on Sat Dec 16 10:31:24 GMT 2023 , Edited by admin on Sat Dec 16 10:31:24 GMT 2023
PRIMARY
EVMPD
SUB195347
Created by admin on Sat Dec 16 10:31:24 GMT 2023 , Edited by admin on Sat Dec 16 10:31:24 GMT 2023
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WIKIPEDIA
DIHYDROETORPHINE
Created by admin on Sat Dec 16 10:31:24 GMT 2023 , Edited by admin on Sat Dec 16 10:31:24 GMT 2023
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EPA CompTox
DTXSID60905082
Created by admin on Sat Dec 16 10:31:24 GMT 2023 , Edited by admin on Sat Dec 16 10:31:24 GMT 2023
PRIMARY
CAS
14357-76-7
Created by admin on Sat Dec 16 10:31:24 GMT 2023 , Edited by admin on Sat Dec 16 10:31:24 GMT 2023
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SMS_ID
100000181584
Created by admin on Sat Dec 16 10:31:24 GMT 2023 , Edited by admin on Sat Dec 16 10:31:24 GMT 2023
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DRUG BANK
DB01450
Created by admin on Sat Dec 16 10:31:24 GMT 2023 , Edited by admin on Sat Dec 16 10:31:24 GMT 2023
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FDA UNII
QQX8S479YV
Created by admin on Sat Dec 16 10:31:24 GMT 2023 , Edited by admin on Sat Dec 16 10:31:24 GMT 2023
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