DIHYDROETORPHINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H35NO4
Molecular Weight	413.5497
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12OC3=C(O)C=CC4=C3[C@@]15CCN(C)[C@]([H])(C4)[C@]56CC[C@@]2(OC)[C@]([H])(C6)[C@](C)(O)CCC

InChI

InChIKey=BRTSNYPDACNMIP-FAWZKKEFSA-N

InChI=1S/C25H35NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,17-18,21,27-28H,5,8-14H2,1-4H3/t17-,18-,21-,22-,23-,24+,25-/m1/s1

HIDE SMILES / InChI

Approval Year

PubMed

Title	Date	PubMed
Pharmacokinetic and pharmacodynamic evaluations of a potent analgesic, dihydroetorphine, in hairless rat.	2001 Feb	11160640
A protective effect against undesirable increase of dihydroetorphine permeation through damaged skin by using pressure-sensitive adhesive tape with an ethylene-vinyl acetate co-polymer membrane.	2001 Jan	11201250
Tolerance to analgesia and dependence liability by topical application of dihydroetorphine to hairless rats.	2001 Jul 6	11448480
Biochemical characterisation of newly developed beta-etorphine and beta-dihydroetorphine derivatives.	2002 May 3	12020678
Discriminative stimulus and antinociceptive effects of dihydroetorphine in rhesus monkeys.	2003 Apr	12601499
Binding affinity to and dependence on some opioids in Sf9 insect cells expressing human mu-opioid receptor.	2003 Sep	12956932
The orvinols and related opioids--high affinity ligands with diverse efficacy profiles.	2004	15032698
Tramadol and dihydroetorphine produce synergistic analgesic effect and postpones acute opiate tolerance in rats.	2005 Dec 25	16344893
Paradoxical relationship between RAVE (relative activity versus endocytosis) values of several opioid receptor agonists and their liability to cause dependence.	2010 Apr	20228826

Name

Type

Language

DIHYDROETORPHINE

Common Name

English

TETRAHYDRO-7.ALPHA.-(1-HYDROXY-1-METHYLBUTYL)-6,14-ENDO-ETHANOORIPAVINE

Common Name

English

Dihydroetorphine [WHO-DD]

Common Name

English

IDS-ND-025

Code

English

6,14-ETHENOMORPHINAN-7-METHANOL, 4,5-EPOXY-18,19-DIHYDRO-3-HYDROXY-6-METHOXY-.ALPHA.,17-DIMETHYL-.ALPHA.-PROPYL-, (.ALPHA.R,5.ALPHA.,7.ALPHA.)

Common Name

English

7,8-DIHYDRO-7.ALPHA.-(1-(R)-HYDROXY-1-METHYLBUTYL)-6,14-ENDOETHANOTETRAHYDROORIPAVINE

Systematic Name

English

Classification Tree Code System Code

DEA NO.

9334