DIHYDROETORPHINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H35NO4
Molecular Weight	413.5497
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12OC3=C(O)C=CC4=C3[C@@]15CCN(C)[C@]([H])(C4)[C@]56CC[C@@]2(OC)[C@]([H])(C6)[C@](C)(O)CCC

InChI

InChIKey=BRTSNYPDACNMIP-FAWZKKEFSA-N

InChI=1S/C25H35NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,17-18,21,27-28H,5,8-14H2,1-4H3/t17-,18-,21-,22-,23-,24+,25-/m1/s1

HIDE SMILES / InChI

Approval Year

PubMed

Title	Date	PubMed
Pharmacokinetic and pharmacodynamic evaluations of a potent analgesic, dihydroetorphine, in hairless rat.	2001 Feb	11160640
Tolerance to analgesia and dependence liability by topical application of dihydroetorphine to hairless rats.	2001 Jul 6	11448480
Biochemical characterisation of newly developed beta-etorphine and beta-dihydroetorphine derivatives.	2002 May 3	12020678
Dihydroetorphine: a potent analgesic: pharmacology, toxicology, pharmacokinetics, and clinical effects.	2002 Winter	12481194
Discriminative stimulus and antinociceptive effects of dihydroetorphine in rhesus monkeys.	2003 Apr	12601499
Synthesis and biological evaluation of 14-alkoxymorphinans. 20. 14-phenylpropoxymetopon: an extremely powerful analgesic.	2003 Sep 11	12954070
The orvinols and related opioids--high affinity ligands with diverse efficacy profiles.	2004	15032698
Tramadol and dihydroetorphine produce synergistic analgesic effect and postpones acute opiate tolerance in rats.	2005 Dec 25	16344893
Paradoxical relationship between RAVE (relative activity versus endocytosis) values of several opioid receptor agonists and their liability to cause dependence.	2010 Apr	20228826

Name

Type

Language

DIHYDROETORPHINE

Common Name

English

TETRAHYDRO-7.ALPHA.-(1-HYDROXY-1-METHYLBUTYL)-6,14-ENDO-ETHANOORIPAVINE

Common Name

English

Dihydroetorphine [WHO-DD]

Common Name

English

IDS-ND-025

Code

English

6,14-ETHENOMORPHINAN-7-METHANOL, 4,5-EPOXY-18,19-DIHYDRO-3-HYDROXY-6-METHOXY-.ALPHA.,17-DIMETHYL-.ALPHA.-PROPYL-, (.ALPHA.R,5.ALPHA.,7.ALPHA.)

Common Name

English

7,8-DIHYDRO-7.ALPHA.-(1-(R)-HYDROXY-1-METHYLBUTYL)-6,14-ENDOETHANOTETRAHYDROORIPAVINE

Systematic Name

English

Classification Tree Code System Code

DEA NO.

9334