Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C25H35NO4 |
Molecular Weight | 413.5497 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 7 / 7 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12OC3=C(O)C=CC4=C3[C@@]15CCN(C)[C@]([H])(C4)[C@]56CC[C@@]2(OC)[C@]([H])(C6)[C@](C)(O)CCC
InChI
InChIKey=BRTSNYPDACNMIP-FAWZKKEFSA-N
InChI=1S/C25H35NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,17-18,21,27-28H,5,8-14H2,1-4H3/t17-,18-,21-,22-,23-,24+,25-/m1/s1
Approval Year
PubMed
Title | Date | PubMed |
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Pharmacokinetic and pharmacodynamic evaluations of a potent analgesic, dihydroetorphine, in hairless rat. | 2001 Feb |
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Tolerance to analgesia and dependence liability by topical application of dihydroetorphine to hairless rats. | 2001 Jul 6 |
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Biochemical characterisation of newly developed beta-etorphine and beta-dihydroetorphine derivatives. | 2002 May 3 |
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Dihydroetorphine: a potent analgesic: pharmacology, toxicology, pharmacokinetics, and clinical effects. | 2002 Winter |
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Discriminative stimulus and antinociceptive effects of dihydroetorphine in rhesus monkeys. | 2003 Apr |
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Synthesis and biological evaluation of 14-alkoxymorphinans. 20. 14-phenylpropoxymetopon: an extremely powerful analgesic. | 2003 Sep 11 |
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The orvinols and related opioids--high affinity ligands with diverse efficacy profiles. | 2004 |
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Tramadol and dihydroetorphine produce synergistic analgesic effect and postpones acute opiate tolerance in rats. | 2005 Dec 25 |
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Paradoxical relationship between RAVE (relative activity versus endocytosis) values of several opioid receptor agonists and their liability to cause dependence. | 2010 Apr |
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DEA NO. |
9334
Created by
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107765
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SUB195347
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DIHYDROETORPHINE
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DTXSID60905082
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14357-76-7
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100000181584
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DB01450
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QQX8S479YV
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)