TINOFEDRINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H21NOS2
Molecular Weight	355.517
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H](NCC=C(C1=CSC=C1)C2=CSC=C2)[C@H](O)C3=CC=CC=C3

InChI

InChIKey=JQSHEDRVRBSFCZ-YWZLYKJASA-N

InChI=1S/C20H21NOS2/c1-15(20(22)16-5-3-2-4-6-16)21-10-7-19(17-8-11-23-13-17)18-9-12-24-14-18/h2-9,11-15,20-22H,10H2,1H3/t15-,20-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7198471 | https://www.ncbi.nlm.nih.gov/pubmed/582394 | https://www.ncbi.nlm.nih.gov/pubmed/582400

Tinofedrine is a dithienylamine derivative patented by Deutsche Gold- und Silber-Scheideanstalt vorm. Roessler for improvement of cerebral and peripheral blood flow. In anesthetized dogs, Tinofedrine causes a remarkable increase of cardiac output by positive inotropic and chronotropic stimulation of the heart and simultaneous reduction of peripheral vascular resistance. In comparison with typical beta-agonists Tinofedrine at isotropically equieffective doses, has a much weaker effect on the heart rate. In coronary circulation, Tinofedrine causes vasodilation so that in a therapeutic dose range increased workload is equalized by sufficient myocardial supply.

Originator

Approval Year

PubMed

Title	Date	PubMed
[The effect of tinofedrine on the EEG].	1978	582394

Patents

Sample Use Guides

In Vivo Use Guide

0.12 to 0.17 mg/kg

Route of Administration: Intravenous

Name

Type

Language

TINOFEDRINE

Official Name

English

(+)-(R)-.ALPHA.-((S)-1-((3,3-DI-3-THIENYLALLYL)AMINO)ETHYL)BENZYL ALCOHOL

Systematic Name

English

TINOFEDRINE [MI]

Common Name

English

tinofedrine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C87053