TINOFEDRINE HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H21NOS2.ClH
Molecular Weight	391.978
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.C[C@H](NCC=C(C1=CSC=C1)C2=CSC=C2)[C@H](O)C3=CC=CC=C3

InChI

InChIKey=BRPBPTNOXZNOML-QNNMEKCMSA-N

InChI=1S/C20H21NOS2.ClH/c1-15(20(22)16-5-3-2-4-6-16)21-10-7-19(17-8-11-23-13-17)18-9-12-24-14-18;/h2-9,11-15,20-22H,10H2,1H3;1H/t15-,20-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	C20H21NOS2
Molecular Weight	355.517
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7198471 | https://www.ncbi.nlm.nih.gov/pubmed/582394 | https://www.ncbi.nlm.nih.gov/pubmed/582400

Tinofedrine is a dithienylamine derivative patented by Deutsche Gold- und Silber-Scheideanstalt vorm. Roessler for improvement of cerebral and peripheral blood flow. In anesthetized dogs, Tinofedrine causes a remarkable increase of cardiac output by positive inotropic and chronotropic stimulation of the heart and simultaneous reduction of peripheral vascular resistance. In comparison with typical beta-agonists Tinofedrine at isotropically equieffective doses, has a much weaker effect on the heart rate. In coronary circulation, Tinofedrine causes vasodilation so that in a therapeutic dose range increased workload is equalized by sufficient myocardial supply.

Originator

Approval Year

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

0.12 to 0.17 mg/kg

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:23:48 GMT 2023` Edited by `admin` on `Fri Dec 15 15:23:48 GMT 2023`
Record UNII	7G83V200MH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TINOFEDRINE HYDROCHLORIDE

Common Name

English

BENZENEMETHANOL, .ALPHA.-(1-((3,3-DI-3-THIENYL-2-PROPENYL)AMINO)ETHYL)-, HYDROCHLORIDE, (R-(R*,S*))-

Systematic Name

English

TINOFEDRINE HYDROCHLORIDE [MI]

Common Name

English

Code System Code Type Description

FDA UNII

7G83V200MH