Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C13H19NO3.ClH |
| Molecular Weight | 273.756 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCOC1=C(OCC2CNCCO2)C=CC=C1
InChI
InChIKey=HJOCKFVCMLCPTP-UHFFFAOYSA-N
InChI=1S/C13H19NO3.ClH/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11;/h3-6,11,14H,2,7-10H2,1H3;1H
Viloxazine is an antidepressant drug was used to treat patients with depression. Viloxazine inhibits noradrenaline uptake. This drug was approved in some Europe countries, but not in the USA, but then it was discontinued because of competition from other drugs. In the frame of drug repositioning, Viloxazine participated in clinical trials for the treatment of attention deficit hyperactivity disorder. Phase II of trials was successfully passed.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Comparative evaluation of the therapeutic efficacy of the antidepressants adepren, linamiphen and emovit]. | 1986 |
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| [Apropos of atypical melancholia with Sustiva (efavirenz)]. | 2001 May-Jun |
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| Simultaneous determination of viloxazine, venlafaxine, imipramine, desipramine, sertraline, and amoxapine in whole blood: comparison of two extraction/cleanup procedures for capillary gas chromatography with nitrogen-phosphorus detection. | 2002 Jul-Aug |
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| Contribution of sleep research to the development of new antidepressants. | 2005 |
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| Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis. | 2005 Dec 9 |
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| Internet-based search of randomised trials relevant to mental health originating in the Arab world. | 2005 Jul 26 |
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| Enhancing central noradrenergic function in depression: is there still a place for a new antidepressant? | 2005 Mar |
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| Gastrointestinal bleeding and massive liver damage in neuroleptic malignant syndrome. | 2005 Sep |
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| [Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations]. | 2006 Jun |
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| Narcolepsy: current treatment options and future approaches. | 2008 Jun |
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| A prognostic system applicable to patients with resectable liver metastasis from colorectal carcinoma staged by positron emission tomography with [18F]fluoro-2-deoxy-D-glucose: role of primary tumor variables. | 2008 May |
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| Adjustment Disorder: epidemiology, diagnosis and treatment. | 2009 Jun 26 |
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| Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography-mass spectrometry. | 2009 Nov |
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| Getting the balance right: Established and emerging therapies for major depressive disorders. | 2010 Sep 7 |
Patents
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| Classification Tree | Code System | Code | ||
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FDA ORPHAN DRUG |
2384
Created by
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NCI_THESAURUS |
C265
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OQW30I1332
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OQW30I1332
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SUB05096MIG
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DTXSID8057722
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100000087898
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142143
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71424
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C152878
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35604-67-2
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DBSALT001262
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252-638-6
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CHEMBL306700
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m11448
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PRIMARY | Merck Index |
ACTIVE MOIETY
SUBSTANCE RECORD
