SODIUM FERULATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H9O4.Na
Molecular Weight	216.1658
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].COC1=CC(\C=C\C([O-])=O)=CC=C1O

InChI

InChIKey=NCTHNHPAQAVBEB-WGCWOXMQSA-M

InChI=1S/C10H10O4.Na/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13;/h2-6,11H,1H3,(H,12,13);/q;+1/p-1/b5-3+;

HIDE SMILES / InChI

Approval Year

Targets

Primary Target	Pharmacology	Potency
Carbonic anhydrase XII 30 Target ID: CHEMBL3242 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20185318	Inhibitor 8297	9.78 µM [Ki]
Carbonic anhydrase IX 35 Target ID: CHEMBL3594 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20185318	Inhibitor 8297	9.87 µM [Ki]
Carbonic anhydrase VII 34 Target ID: CHEMBL2326 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20185318	Inhibitor 8297	7.41 µM [Ki]
Carbonic anhydrase XIV 22 Target ID: CHEMBL3510 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20185318	Inhibitor 8297	9.43 µM [Ki]
Carbonic anhydrase VA 25 Target ID: CHEMBL4789 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20185318	Inhibitor 8297	7.04 µM [Ki]
Carbonic anhydrase I 62 Target ID: CHEMBL261 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20185318	Inhibitor 8297	2.89 µM [Ki]
Carbonic anhydrase II 88 Target ID: CHEMBL205 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20185318	Inhibitor 8297	2.4 µM [Ki]
Fibroblast growth factor receptor 1 45 Target ID: CHEMBL3650 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26473837	Inhibitor 8297	3.78 µM [IC50]

PubMed

Title	Date	PubMed
Isolation and quantitation of steroids from normal human amniotic fluid.	1968 Aug	4234060
Curcumin and curcumin derivatives inhibit Tat-mediated transactivation of type 1 human immunodeficiency virus long terminal repeat.	1998 Jan-Feb	9561563
Free radical scavengers and antioxidants from Baccharis grisebachii.	2004 Dec	15507329
Ferulic acid inhibits endothelial cell proliferation through NO down-regulating ERK1/2 pathway.	2004 Dec 15	15486966
Influence of ferulic acid on circulatory prooxidant-antioxidant status during alcohol and PUFA induced toxicity.	2004 Sep	15381826
Ferulic acid inhibits vascular smooth muscle cell proliferation induced by angiotensin II.	2004 Sep 19	15363954
Interactions of human serum albumin with chlorogenic acid and ferulic acid.	2004 Sep 24	15374625
Ferulic acid, a natural protector against carbon tetrachloride-induced toxicity.	2005 Aug	16011737
Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans.	2005 Feb	15309457
Antioxidant and antigenotoxic effects of plant cell wall hydroxycinnamic acids in cultured HT-29 cells.	2005 Jun	15841493
Modulation of hepatic phase II phenol sulfotransferase and antioxidant status by phenolic acids in rats.	2006 Aug	16443358
Synergistic salubrious effect of ferulic acid and ascorbic acid on membrane-bound phosphatases and lysosomal hydrolases during experimental myocardial infarction in rats.	2006 Dec 23	17045618
Synergistic interactions of ferulic acid with ascorbic acid: its cardioprotective role during isoproterenol induced myocardial infarction in rats.	2006 Feb	16444596
Attenuation of abnormalities in the lipid metabolism during experimental myocardial infarction induced by isoproterenol in rats: beneficial effect of ferulic acid and ascorbic acid.	2006 May	16635105
Analysis of interaction property of bioactive components in Danggui Buxue Decoction with protein by microdialysis coupled with HPLC-DAD-MS.	2007 Jun 1	17383242
Predicting the biological activities of 2-methoxyphenol antioxidants: effects of dimers.	2007 Mar-Apr	17436566
Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin.	2008 Aug 8	18583042
Influence of ferulic acid on nicotine-induced lipid peroxidation, DNA damage and inflammation in experimental rats as compared to N-acetylcysteine.	2008 Jan 20	18068289
Restoration of altered microRNA expression in the ischemic heart with resveratrol.	2010 Dec 23	21203465
Ferulic acid protects against carbon tetrachloride-induced liver injury in mice.	2011 Apr 11	21291945
Celastrol inhibits Tat-mediated human immunodeficiency virus (HIV) transcription and replication.	2011 Jul 29	21763500
Interaction of cinnamic acid derivatives with commercial hypoglycemic drugs on 2-deoxyglucose uptake in 3T3-L1 adipocytes.	2011 Sep 28	21870829
Anticonvulsant and behavioral effects observed in mice following treatment with an ester derivative of ferulic acid: Isopentyl ferulate.	2015 Dec 5	26456888
Investigation of the effects of some drugs and phenolic compounds on human dihydrofolate reductase activity.	2015 Mar	25418905

Patents

Name

Type

Language

SODIUM FERULATE

Official Name

English

SODIUM 3-METHOXY-4-HYDROXYCINNAMATE

Systematic Name

English

CINNAMIC ACID, 4-HYDROXY-3-METHOXY-, MONOSODIUM SALT

Common Name

English

SODIUM FERULATE [INCI]

Common Name

English

FEMA NO. 3812

Code

English

Sodium ferulate [WHO-DD]

Common Name

English

SODIUM 3-METHOXY-4-HYDROXYCINNAMATE [FHFI]

Common Name

English

Code System Code Type Description

WIKIPEDIA

SODIUM FERULATE