XYLAMIDINE

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H24N2O2
Molecular Weight	312.4061
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=CC(OC(C)CNC(=N)CC2=CC=CC(C)=C2)=C1

InChI

InChIKey=JRYTUFKIORWTNI-UHFFFAOYSA-N

InChI=1S/C19H24N2O2/c1-14-6-4-7-16(10-14)11-19(20)21-13-15(2)23-18-9-5-8-17(12-18)22-3/h4-10,12,15H,11,13H2,1-3H3,(H2,20,21)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1762059 | https://www.ncbi.nlm.nih.gov/pubmed/2623027 | https://www.ncbi.nlm.nih.gov/pubmed/15527744

Xylamidine is a peripherally-restricted antagonist of 5HT2A and 5HT1A receptor. It is used to study the role of the serotonin receptors in the regulation of food intake, cardiovascular function, and regulation of body temperature.

Approval Year

PubMed

Title	Date	PubMed
Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction.	2004 Dec 3	15527744
Differential effects of nitroblue tetrazolium on the hemodynamic responses elicited by activation of alpha1-adrenoceptors and 5-HT2 receptors in conscious rats.	2006 Mar 27	16527267
5-HT activates vagal afferent cell bodies in vivo: role of 5-HT2 and 5-HT3 receptors.	2006 Nov 17	17029799

Name

Type

Language

XYLAMIDINE

Common Name

English

N-(2-(M-METHOXYPHENOXY)PROPYL)-2-M-TOLYLACETAMIDINE

Systematic Name

English

BENZENEETHANIMIDAMIDE, N-(2-(3-METHOXYPHENOXY)PROPYL)-3-METHYL-

Systematic Name

English

Code System Code Type Description

CAS

6443-50-1