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Details

Stereochemistry RACEMIC
Molecular Formula C19H24N2O2
Molecular Weight 312.4061
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of XYLAMIDINE

SMILES

COC1=CC(OC(C)CNC(=N)CC2=CC=CC(C)=C2)=CC=C1

InChI

InChIKey=JRYTUFKIORWTNI-UHFFFAOYSA-N
InChI=1S/C19H24N2O2/c1-14-6-4-7-16(10-14)11-19(20)21-13-15(2)23-18-9-5-8-17(12-18)22-3/h4-10,12,15H,11,13H2,1-3H3,(H2,20,21)

HIDE SMILES / InChI

Description

Xylamidine is a peripherally-restricted antagonist of 5HT2A and 5HT1A receptor. It is used to study the role of the serotonin receptors in the regulation of food intake, cardiovascular function, and regulation of body temperature.

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
5-HT activates vagal afferent cell bodies in vivo: role of 5-HT2 and 5-HT3 receptors.
2006-11-17
Differential effects of nitroblue tetrazolium on the hemodynamic responses elicited by activation of alpha1-adrenoceptors and 5-HT2 receptors in conscious rats.
2006-03-27
Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction.
2004-12-03
Role of central 5-HT2 receptors in mediating head bobs and body shakes in the rabbit.
2004-03
Neurogenic dural protein extravasation induced by meta-chlorophenylpiperazine (mCPP) involves nitric oxide and 5-HT2B receptor activation.
2003-03
Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms.
1991-12
Effects of xylamidine on peripheral 5-hydroxytryptamine-induced anorexia.
1989-12
Name Type Language
BENZENEETHANIMIDAMIDE, N-(2-(3-METHOXYPHENOXY)PROPYL)-3-METHYL-
Preferred Name English
XYLAMIDINE
Common Name English
N-(2-(M-METHOXYPHENOXY)PROPYL)-2-M-TOLYLACETAMIDINE
Systematic Name English
Code System Code Type Description
CAS
6443-50-1
Created by admin on Mon Mar 31 18:38:16 GMT 2025 , Edited by admin on Mon Mar 31 18:38:16 GMT 2025
PRIMARY
PUBCHEM
22951
Created by admin on Mon Mar 31 18:38:16 GMT 2025 , Edited by admin on Mon Mar 31 18:38:16 GMT 2025
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MESH
C005894
Created by admin on Mon Mar 31 18:38:16 GMT 2025 , Edited by admin on Mon Mar 31 18:38:16 GMT 2025
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FDA UNII
NY0PC84NZK
Created by admin on Mon Mar 31 18:38:16 GMT 2025 , Edited by admin on Mon Mar 31 18:38:16 GMT 2025
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EPA CompTox
DTXSID90863843
Created by admin on Mon Mar 31 18:38:16 GMT 2025 , Edited by admin on Mon Mar 31 18:38:16 GMT 2025
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WIKIPEDIA
XYLAMIDINE
Created by admin on Mon Mar 31 18:38:16 GMT 2025 , Edited by admin on Mon Mar 31 18:38:16 GMT 2025
PRIMARY
ACTIVE MOIETY
Structure of XYLAMIDINE
NIH
NCATS
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