SAMERIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H34N2O
Molecular Weight	330.5075
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCN1CCC(CC1)(C(=O)N(C)CC)C2=CC=CC=C2

InChI

InChIKey=TYWUGCGYWNSRPS-UHFFFAOYSA-N

InChI=1S/C21H34N2O/c1-4-6-7-11-16-23-17-14-21(15-18-23,20(24)22(3)5-2)19-12-9-8-10-13-19/h8-10,12-13H,4-7,11,14-18H2,1-3H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12538214 | https://www.ncbi.nlm.nih.gov/pubmed/9689276 | https://adisinsight.springer.com/drugs/800005282

Sameridine was developed as a compound with both local anesthetic and opioid properties (partial micro-opioid receptor agonist). This drug participated in clinical trials when administered intrathecally to provide anesthesia for surgery and extended postoperative analgesia. However, further development of this drug was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Determination of sameridine in blood plasma by nitrogen-selective gas chromatography.	2001 Aug 25	11522054
Novel local anaesthetics and novel indications for local anaesthetics.	2001 Dec	17019174
The effects on hypercarbic ventilatory response of sameridine compared to morphine and placebo.	2001 Feb	11159263
Hypercarbic and hypoxic ventilatory responses after intrathecal administration of bupivacaine and sameridine.	2003 Feb	12538214

Patents

Sample Use Guides

In Vivo Use Guide

Twenty-four healthy volunteers received either 25 mg of sameridine or 15 mg of bupivacaine intrathecally. Ventilation was measured by pneumotachography and in-line capnography

Route of Administration: Other

Name

Type

Language

SAMERIDINE

Official Name

English

sameridine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C241