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Details

Stereochemistry RACEMIC
Molecular Formula 2C10H13N3O2.H2O4S
Molecular Weight 512.537
Optical Activity ( + / - )
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GUANOXAN SULFATE

SMILES

OS(O)(=O)=O.NC(=N)NCC1COC2=CC=CC=C2O1.NC(=N)NCC3COC4=CC=CC=C4O3

InChI

InChIKey=NSGHAKPGHCNTPS-UHFFFAOYSA-N
InChI=1S/2C10H13N3O2.H2O4S/c2*11-10(12)13-5-7-6-14-8-3-1-2-4-9(8)15-7;1-5(2,3)4/h2*1-4,7H,5-6H2,(H4,11,12,13);(H2,1,2,3,4)

HIDE SMILES / InChI

Description

Guanoxan is 2-guanidinomethylbenzo-1,4-dioxan. It acts as a blocker of alpha-2 adrenoceptors. The clinical use of this drug has been in the treatment of hypertension. Both systolic and diastolic pressures are lowered in the lying and standing positions.

Originator

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
Dihydroergotamine: an effective treatment for postural hypotension due to antihypertensive drugs (ganglion-blocking agents excepted).
1976

Sample Use Guides

In Vivo Use Guide
The drug may be given orally initially at a dose of 20 mg. daily and doubled every fourth day until an effect is obtained. Where more rapid effect is desired, a loading dose of 40 mg. may be used.
Route of Administration: Oral
Name Type Language
GUANOXAN SULFATE
MART.   MI   USAN   WHO-DD  
USAN  
Official Name English
ENVACAR
Preferred Name English
GUANOXAN SULPHATE
Common Name English
GUANOXAN SULFATE [USAN]
Common Name English
3-01003
Code English
NSC-108162
Code English
(1,4-BENZODIOXAN-2-YL-METHYL)GUANIDINE SULFATE (2:1)
Systematic Name English
GUANIDINE, (2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLMETHYL)-, SULFATE (2:1)
Systematic Name English
GUANIDINE, (2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLMETHYL)-, SULPHATE (2:1)
Systematic Name English
(1,4-BENZODIOXAN-2-YL-METHYL)GUANIDINE SULPHATE (2:1)
Systematic Name English
Guanoxan sulfate [WHO-DD]
Common Name English
GUANOXAN SULFATE [MART.]
Common Name English
GUANOXAN SULFATE [MI]
Common Name English
Code System Code Type Description
SMS_ID
100000086696
Created by admin on Mon Mar 31 17:45:24 GMT 2025 , Edited by admin on Mon Mar 31 17:45:24 GMT 2025
PRIMARY
MERCK INDEX
m5873
Created by admin on Mon Mar 31 17:45:24 GMT 2025 , Edited by admin on Mon Mar 31 17:45:24 GMT 2025
PRIMARY Merck Index
FDA UNII
N6IT80R85G
Created by admin on Mon Mar 31 17:45:24 GMT 2025 , Edited by admin on Mon Mar 31 17:45:24 GMT 2025
PRIMARY
EVMPD
SUB02432MIG
Created by admin on Mon Mar 31 17:45:24 GMT 2025 , Edited by admin on Mon Mar 31 17:45:24 GMT 2025
PRIMARY
NCI_THESAURUS
C174743
Created by admin on Mon Mar 31 17:45:24 GMT 2025 , Edited by admin on Mon Mar 31 17:45:24 GMT 2025
PRIMARY
NSC
108162
Created by admin on Mon Mar 31 17:45:24 GMT 2025 , Edited by admin on Mon Mar 31 17:45:24 GMT 2025
PRIMARY
ChEMBL
CHEMBL76725
Created by admin on Mon Mar 31 17:45:24 GMT 2025 , Edited by admin on Mon Mar 31 17:45:24 GMT 2025
PRIMARY
PUBCHEM
23724918
Created by admin on Mon Mar 31 17:45:24 GMT 2025 , Edited by admin on Mon Mar 31 17:45:24 GMT 2025
PRIMARY
DRUG BANK
DBSALT002676
Created by admin on Mon Mar 31 17:45:24 GMT 2025 , Edited by admin on Mon Mar 31 17:45:24 GMT 2025
PRIMARY
CAS
5714-04-5
Created by admin on Mon Mar 31 17:45:24 GMT 2025 , Edited by admin on Mon Mar 31 17:45:24 GMT 2025
PRIMARY
ACTIVE MOIETY
Structure of GUANOXAN
SUBSTANCE RECORD
Structure of GUANOXAN SULFATE
NIH
NCATS
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