Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H8ClN4O2S.Na |
| Molecular Weight | 306.704 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].NC1=CC=C(C=C1)S(=O)(=O)[N-]C2=CC=C(Cl)N=N2
InChI
InChIKey=ODWMXYHUKDMPTR-UHFFFAOYSA-N
InChI=1S/C10H8ClN4O2S.Na/c11-9-5-6-10(14-13-9)15-18(16,17)8-3-1-7(12)2-4-8;/h1-6H,12H2;/q-1;+1
Sulfachlorpyridazine is a broad spectrum antibacterial compound which is effective
in the treatment of infections caused by gram-positive and gram-negative
organisms that are commonly susceptible to sulfonamide therapy and which has
been proven by laboratory and field experiments to be highly effective against
diseases caused by Escherichia coli. Sulfachlorpyridazine has a rapid onset of action in several species of animals
following both oral and parenteral administration. Sulfachlorpyridazine (brand name Vetisulid) is especially indicated for the treatment of diarrhea caused or
complicated by E. coli (colibacillosis) in calves under 1 month of age: Vetisulid
powder is also indicated for the treatment of colibacillosis in swine. Sulfachlorpyridazine is a dihydropteroate synthase inhibitor.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL614446 |
|||
Target ID: CHEMBL614409 |
|||
Target ID: CHEMBL2364668 |
18.0 nM [IC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Curative | Vetisulid Approved UseVetisulid Injection (Sodium Sulfachlorpyridazine Injection), is especially indicated
for the treatment of diarrhea caused or complicated by E. coli (colibacillosis) in
calves under 1 month of age. |
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
21.5 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7752306/ |
20 mg/kg single, intramuscular dose: 20 mg/kg route of administration: Intramuscular experiment type: SINGLE co-administered: TRIMETHOPRIM |
SULFACHLORPYRIDAZINE plasma | Equus caballus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
12121 μg × min/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7752306/ |
20 mg/kg single, intramuscular dose: 20 mg/kg route of administration: Intramuscular experiment type: SINGLE co-administered: TRIMETHOPRIM |
SULFACHLORPYRIDAZINE plasma | Equus caballus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
270 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7752306/ |
20 mg/kg single, intramuscular dose: 20 mg/kg route of administration: Intramuscular experiment type: SINGLE co-administered: TRIMETHOPRIM |
SULFACHLORPYRIDAZINE plasma | Equus caballus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Drugs as allergens: detection and combining site specificities of IgE antibodies to sulfamethoxazole. | 1988 Dec |
|
| Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. | 1995 Aug |
|
| Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia. | 1996 Apr |
|
| Stability of sulfonamides, nitrofurans, and chloramphenicol residues in preserved raw milk samples measured by liquid chromatography. | 2002 Nov-Dec |
|
| In vitro susceptibility of Ornithobacterium rhinotracheale to several antimicrobial drugs. | 2003 Apr-Jun |
|
| Preliminary evaluation of a lateral flow immunoassay device for screening urine samples for the presence of sulphamethazine. | 2003 Jul |
|
| Liquid chromatography-fluorescence detection for simultaneous analysis of sulfonamide residues in honey. | 2003 Jun |
|
| Comparison of a liquid chromatographic method with ultraviolet and ion-trap tandem mass spectrometric detection for the simultaneous determination of sulfadiazine and trimethoprim in plasma from dogs. | 2003 May 5 |
|
| Quantitative analysis of twelve sulfonamides in honey after acidic hydrolysis by high-performance liquid chromatography with post-column derivatization and fluorescence detection. | 2004 Aug 20 |
|
| Pollution-induced community tolerance of soil microbial communities caused by the antibiotic sulfachloropyridazine. | 2004 Feb 15 |
|
| Antimicrobial use in the treatment of calf diarrhea. | 2004 Jan-Feb |
|
| In vitro toxicity of antimicrobials on RTG-2 and RTL-W1 fish cell lines. | 2005 Jul |
|
| A lysimeter experiment to investigate the leaching of veterinary antibiotics through a clay soil and comparison with field data. | 2005 Mar |
|
| The effect of pH and ionic strength on the sorption of sulfachloropyridazine, tylosin, and oxytetracycline to soil. | 2006 Apr |
|
| Application of capillary zone electrophoresis with large-volume sample stacking to the sensitive determination of sulfonamides in meat and ground water. | 2006 Oct |
|
| The dissipation and transport of veterinary antibiotics in a sandy loam soil. | 2007 Feb |
|
| A rapid assay for dihydropteroate synthase activity suitable for identification of inhibitors. | 2007 Jan 15 |
|
| Development of an enzyme-linked immunosorbent assay for seven sulfonamide residues and investigation of matrix effects from different food samples. | 2007 Mar 21 |
|
| Immunochemical assays for direct sulfonamide antibiotic detection in milk and hair samples using antibody derivatized magnetic nanoparticles. | 2008 Feb 13 |
|
| Determination of ten sulphonamides in egg by liquid chromatography-tandem mass spectrometry. | 2009 Apr 1 |
|
| Determination of sulfonamide residues in water samples by in-line solid-phase extraction-capillary electrophoresis. | 2009 Apr 10 |
|
| Analytical method for simultaneous determination of pesticide and veterinary drug residues in milk by CE-MS. | 2009 May |
|
| A confirmatory method for the simultaneous extraction, separation, identification and quantification of Tetracycline, Sulphonamide, Trimethoprim and Dapsone residues in muscle by ultra-high-performance liquid chromatography-tandem mass spectrometry according to Commission Decision 2002/657/EC. | 2009 Nov 13 |
|
| A new and simple method to determine trace levels of sulfonamides in honey by high performance liquid chromatography with fluorescence detection. | 2009 Oct 23 |
|
| Sulfonamide antibiotics embedded in high silica zeolite Y: a combined experimental and theoretical study of host-guest and guest-guest interactions. | 2010 Jun 15 |
Patents
Sample Use Guides
Calves: The recommended daily dose is 30 to 45 mg of sulfachlorpyridazine per lb
of body weight administered in 2 divided doses for 1 to 5 days, as follows:
Vetisulid Injection (Sodium Sulfachlorpyridazine Injection) – Administer
intravenously 1 mL per 10 lb of body weight morning and night.
It is suggested that therapy be initiated by administering Vetisulid Injection intravenously and continuing therapy with oral administration of either Vetisulid
Boluses or Vetisulid Powder.
Route of Administration:
Intravenous
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PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
