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Details

Stereochemistry ACHIRAL
Molecular Formula C10H8ClN4O2S.Na
Molecular Weight 306.704
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SULFACHLORPYRIDAZINE SODIUM

SMILES

[Na+].NC1=CC=C(C=C1)S(=O)(=O)[N-]C2=NN=C(Cl)C=C2

InChI

InChIKey=ODWMXYHUKDMPTR-UHFFFAOYSA-N
InChI=1S/C10H8ClN4O2S.Na/c11-9-5-6-10(14-13-9)15-18(16,17)8-3-1-7(12)2-4-8;/h1-6H,12H2;/q-1;+1

HIDE SMILES / InChI

Description

Sulfachlorpyridazine is a broad spectrum antibacterial compound which is effective in the treatment of infections caused by gram-positive and gram-negative organisms that are commonly susceptible to sulfonamide therapy and which has been proven by laboratory and field experiments to be highly effective against diseases caused by Escherichia coli. Sulfachlorpyridazine has a rapid onset of action in several species of animals following both oral and parenteral administration. Sulfachlorpyridazine (brand name Vetisulid) is especially indicated for the treatment of diarrhea caused or complicated by E. coli (colibacillosis) in calves under 1 month of age: Vetisulid powder is also indicated for the treatment of colibacillosis in swine. Sulfachlorpyridazine is a dihydropteroate synthase inhibitor.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
18.0 nM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Vetisulid

Cmax

ValueDoseCo-administeredAnalytePopulation
21.5 μg/mL
20 mg/kg single, intramuscular
SULFACHLORPYRIDAZINE plasma
Equus caballus

AUC

ValueDoseCo-administeredAnalytePopulation
12121 μg × min/mL
20 mg/kg single, intramuscular
SULFACHLORPYRIDAZINE plasma
Equus caballus

T1/2

ValueDoseCo-administeredAnalytePopulation
270 min
20 mg/kg single, intramuscular
SULFACHLORPYRIDAZINE plasma
Equus caballus

PubMed

Sample Use Guides

In Vivo Use Guide
Calves: The recommended daily dose is 30 to 45 mg of sulfachlorpyridazine per lb of body weight administered in 2 divided doses for 1 to 5 days, as follows: Vetisulid Injection (Sodium Sulfachlorpyridazine Injection) – Administer intravenously 1 mL per 10 lb of body weight morning and night. It is suggested that therapy be initiated by administering Vetisulid Injection intravenously and continuing therapy with oral administration of either Vetisulid Boluses or Vetisulid Powder.
Route of Administration: Intravenous
In Vitro Use Guide
Sulfachlorpyridazine inhibited equine Salmonella strains with MIC50=16 ug/ml.