Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H8ClN4O2S.Na |
| Molecular Weight | 306.704 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].NC1=CC=C(C=C1)S(=O)(=O)[N-]C2=NN=C(Cl)C=C2
InChI
InChIKey=ODWMXYHUKDMPTR-UHFFFAOYSA-N
InChI=1S/C10H8ClN4O2S.Na/c11-9-5-6-10(14-13-9)15-18(16,17)8-3-1-7(12)2-4-8;/h1-6H,12H2;/q-1;+1
| Molecular Formula | C10H9ClN4O2S |
| Molecular Weight | 284.722 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Sulfachlorpyridazine is a broad spectrum antibacterial compound which is effective
in the treatment of infections caused by gram-positive and gram-negative
organisms that are commonly susceptible to sulfonamide therapy and which has
been proven by laboratory and field experiments to be highly effective against
diseases caused by Escherichia coli. Sulfachlorpyridazine has a rapid onset of action in several species of animals
following both oral and parenteral administration. Sulfachlorpyridazine (brand name Vetisulid) is especially indicated for the treatment of diarrhea caused or
complicated by E. coli (colibacillosis) in calves under 1 month of age: Vetisulid
powder is also indicated for the treatment of colibacillosis in swine. Sulfachlorpyridazine is a dihydropteroate synthase inhibitor.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL614446 |
|||
Target ID: CHEMBL614409 |
|||
Target ID: CHEMBL2364668 |
18.0 nM [IC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Curative | Vetisulid Approved UseVetisulid Injection (Sodium Sulfachlorpyridazine Injection), is especially indicated
for the treatment of diarrhea caused or complicated by E. coli (colibacillosis) in
calves under 1 month of age. |
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
21.5 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7752306/ |
20 mg/kg single, intramuscular dose: 20 mg/kg route of administration: Intramuscular experiment type: SINGLE co-administered: TRIMETHOPRIM |
SULFACHLORPYRIDAZINE plasma | Equus caballus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
12121 μg × min/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7752306/ |
20 mg/kg single, intramuscular dose: 20 mg/kg route of administration: Intramuscular experiment type: SINGLE co-administered: TRIMETHOPRIM |
SULFACHLORPYRIDAZINE plasma | Equus caballus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
270 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7752306/ |
20 mg/kg single, intramuscular dose: 20 mg/kg route of administration: Intramuscular experiment type: SINGLE co-administered: TRIMETHOPRIM |
SULFACHLORPYRIDAZINE plasma | Equus caballus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Drugs as allergens: detection and combining site specificities of IgE antibodies to sulfamethoxazole. | 1988 Dec |
|
| Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. | 1995 Aug |
|
| Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia. | 1996 Apr |
|
| Development of an ELISA for sulfachlorpyridazine and investigation of matrix effects from different sample extraction procedures. | 2001 Jan |
|
| Stability of sulfonamides, nitrofurans, and chloramphenicol residues in preserved raw milk samples measured by liquid chromatography. | 2002 Nov-Dec |
|
| In vitro susceptibility of Ornithobacterium rhinotracheale to several antimicrobial drugs. | 2003 Apr-Jun |
|
| Preliminary evaluation of a lateral flow immunoassay device for screening urine samples for the presence of sulphamethazine. | 2003 Jul |
|
| Liquid chromatography-fluorescence detection for simultaneous analysis of sulfonamide residues in honey. | 2003 Jun |
|
| Comparison of a liquid chromatographic method with ultraviolet and ion-trap tandem mass spectrometric detection for the simultaneous determination of sulfadiazine and trimethoprim in plasma from dogs. | 2003 May 5 |
|
| Fate of veterinary antibiotics in a macroporous tile drained clay soil. | 2004 May |
|
| Effects of sulfachlorpyridazine in MS.3-arable land: a multispecies soil system for assessing the environmental fate and effects of veterinary medicines. | 2005 Apr |
|
| In vitro toxicity of antimicrobials on RTG-2 and RTL-W1 fish cell lines. | 2005 Jul |
|
| Estimation of soil sorption coefficients of veterinary pharmaceuticals from soil properties. | 2006 Apr |
|
| Multiresidue determination of sulfonamides in edible catfish, shrimp and salmon tissues by high-performance liquid chromatography with postcolumn derivatization and fluorescence detection. | 2006 Aug 18 |
|
| Changes in antibacterial activity of triclosan and sulfa drugs due to photochemical transformations. | 2006 Jun |
|
| Multiwalled carbon nanotubes as sorbent for on-line coupling of solid-phase extraction to high-performance liquid chromatography for simultaneous determination of 10 sulfonamides in eggs and pork. | 2006 Sep 15 |
|
| The dissipation and transport of veterinary antibiotics in a sandy loam soil. | 2007 Feb |
|
| Development of an enzyme-linked immunosorbent assay for seven sulfonamide residues and investigation of matrix effects from different food samples. | 2007 Mar 21 |
|
| [Simultaneous determination of nine sulfonamide residues in milk using solid phase extraction and high performance liquid chromatography]. | 2007 Sep |
|
| Application of matrix solid-phase dispersion and high-performance liquid chromatography for determination of sulfonamides in honey. | 2008 Jan-Feb |
|
| Determination of ten sulphonamides in egg by liquid chromatography-tandem mass spectrometry. | 2009 Apr 1 |
|
| Analytical method for simultaneous determination of pesticide and veterinary drug residues in milk by CE-MS. | 2009 May |
|
| A new and simple method to determine trace levels of sulfonamides in honey by high performance liquid chromatography with fluorescence detection. | 2009 Oct 23 |
Patents
Sample Use Guides
Calves: The recommended daily dose is 30 to 45 mg of sulfachlorpyridazine per lb
of body weight administered in 2 divided doses for 1 to 5 days, as follows:
Vetisulid Injection (Sodium Sulfachlorpyridazine Injection) – Administer
intravenously 1 mL per 10 lb of body weight morning and night.
It is suggested that therapy be initiated by administering Vetisulid Injection intravenously and continuing therapy with oral administration of either Vetisulid
Boluses or Vetisulid Powder.
Route of Administration:
Intravenous
| Substance Class |
Chemical
Created
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Edited
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| Record UNII |
N1LMA4960O
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| Record Status |
Validated (UNII)
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| Record Version |
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PARENT -> SALT/SOLVATE |
