U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C8H9NO2.ClH
Molecular Weight 187.623
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 4-(Aminomethyl)benzoic acid hydrochloride

SMILES

Cl.NCC1=CC=C(C=C1)C(O)=O

InChI

InChIKey=IQKLOQHWKQYTQZ-UHFFFAOYSA-N
InChI=1S/C8H9NO2.ClH/c9-5-6-1-3-7(4-2-6)8(10)11;/h1-4H,5,9H2,(H,10,11);1H

HIDE SMILES / InChI
Aminomethylbenzoic acid (or p-aminomethylbenzoic acid, or PAMBA) an antifibrinolytic agent. This drug has been used for the treatment of internal hemorrhage during chronic disseminated intravascular coagulation.

Approval Year

PubMed

PubMed

TitleDatePubMed
[Hematuria due to increased urokinase activity. Its successful treatment with p-aminomethylbenzoic acid (PAMBA)].
1965 Oct 8
Flow-injection chemiluminescence determination of aminomethylbenzoic acid and aminophylline based on N-bromosuccinimide-luminol reaction.
2004 Feb 27
Activation of vagal afferents in the rat duodenum by protein digests requires PepT1.
2005 Jun
[Clinical investigation on the effect of intravesical instillation of antifibrinolytic agents with bacillus Calmette-Guerin on preventing bladder cancer recurrence].
2005 Nov 15
Radiosynthesis and evaluation of [11C]BTA-1 and [11C]3'-Me-BTA-1 as potential radiotracers for in vivo imaging of beta-amyloid plaques.
2007
Influence of a 4-aminomethylbenzoic acid residue on competitive fragmentation pathways during collision-induced dissociation of metal-cationized peptides.
2007
Cowpea bruchid Callosobruchus maculatus counteracts dietary protease inhibitors by modulating propeptides of major digestive enzymes.
2007 Jun
Spectrophotometric determination of aminomethylbenzoic acid using sodium 1,2-naphthoquinone-4-sulfonate as the chemical derivative chromogenic reagent.
2007 Mar
Substituent effects on the energetics and aromaticity of aminomethylbenzoic acids.
2007 Oct 25
The effect of intravesical instillation of antifibrinolytic agents on bacillus Calmette-Guerin treatment of superficial bladder cancer: a pilot study.
2008 Apr
The effect of intravesical instillation of antifibrinolytic agents on bacillus Calmette-Guerin treatment of superficial bladder cancer: A pilot study.
2008 Jul
Incidence and clinical characteristics of group A rotavirus infections among children admitted to hospital in Kilifi, Kenya.
2008 Jul 22
Simple spectrophotometric method for determination of paroxetine in tablets using 1,2-naphthoquinone-4-sulphonate as a chromogenic reagent.
2009
Anti-fibrinolytic agents in post partum haemorrhage: a systematic review.
2009 Jul 15
Microbicides development programme: engaging the community in the standard of care debate in a vaginal microbicide trial in Mwanza, Tanzania.
2009 Oct 9
The role of transporters in the pharmacokinetics of orally administered drugs.
2009 Sep
Transport of the photodynamic therapy agent 5-aminolevulinic acid by distinct H+-coupled nutrient carriers coexpressed in the small intestine.
2010 Jan
Tanzanian farmers' knowledge and attitudes to GM biotechnology and the potential use of GM crops to provide improved levels of food security. A Qualitative Study.
2010 Jul 12
Clinical pancreatology I: Pancreatic medical history.
2010 Nov
Choice of fluids for resuscitation in children with severe infection and shock: systematic review.
2010 Sep 2
Patents
Name Type Language
4-(Aminomethyl)benzoic acid hydrochloride
Systematic Name English
Benzoic acid, 4-(aminomethyl)-, hydrochloride (1:1)
Systematic Name English
Benzoic acid, 4-(aminomethyl)-, hydrochloride
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID10217980
Created by admin on Sat Dec 16 12:21:42 GMT 2023 , Edited by admin on Sat Dec 16 12:21:42 GMT 2023
PRIMARY
PUBCHEM
105553
Created by admin on Sat Dec 16 12:21:42 GMT 2023 , Edited by admin on Sat Dec 16 12:21:42 GMT 2023
PRIMARY
CAS
67688-72-6
Created by admin on Sat Dec 16 12:21:42 GMT 2023 , Edited by admin on Sat Dec 16 12:21:42 GMT 2023
PRIMARY
ECHA (EC/EINECS)
266-903-9
Created by admin on Sat Dec 16 12:21:42 GMT 2023 , Edited by admin on Sat Dec 16 12:21:42 GMT 2023
PRIMARY
FDA UNII
MVW2TZW37D
Created by admin on Sat Dec 16 12:21:42 GMT 2023 , Edited by admin on Sat Dec 16 12:21:42 GMT 2023
PRIMARY