Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C24H30NO4.Br |
| Molecular Weight | 476.403 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Br-].CO[C@@H]1C[C@H]2C[C@H](C[C@@H]1[N+]2(C)C)OC(=O)C(O)(C3=CC=CC=C3)C4=CC=CC=C4
InChI
InChIKey=OENFXACOWSBKMV-YGRUNEGGSA-M
InChI=1S/C24H30NO4.BrH/c1-25(2)19-14-20(16-21(25)22(15-19)28-3)29-23(26)24(27,17-10-6-4-7-11-17)18-12-8-5-9-13-18;/h4-13,19-22,27H,14-16H2,1-3H3;1H/q+1;/p-1/t19-,20-,21+,22-;/m1./s1
Tropenziline is an antispasmodic. It exerted an enhancement of the vasoconstrictor responses of hepatic artery to low concentrations of adrenaline with no effect on the portal venous bed in the isolated perfused liver of rabbit. Tropenziline interferes with nervous transmission in the vagal plexus of the intestine and thus exerts a spasmolytic effect, which has also been confirmed clinically.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The actions of atropine, tropenziline and N-butyl hyoscine bromide on the isolated distal colon of the guinea-pig: a comparison of their activities and mechanisms of action. | 1969 Oct |
|
| A study of the inhibition of adrenaline-induced vasoconstriction in the isolated perfused liver of rabbit. | 1990 Nov |
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NCI_THESAURUS |
C29698
Created by
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NCI_THESAURUS |
C66880
Created by
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DTXSID10931715
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1029
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143-92-0
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91800276
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SUB11341MIG
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MNQ72KR8VM
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C152763
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100000076978
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CHEMBL2111174
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205-612-3
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ACTIVE MOIETY
SUBSTANCE RECORD
