Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H25I2NO3 |
| Molecular Weight | 617.2584 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCC1=C(C(=O)C2=CC(I)=C(OCCNCC)C(I)=C2)C3=CC=CC=C3O1
InChI
InChIKey=VXOKDLACQICQFA-UHFFFAOYSA-N
InChI=1S/C23H25I2NO3/c1-3-5-9-20-21(16-8-6-7-10-19(16)29-20)22(27)15-13-17(24)23(18(25)14-15)28-12-11-26-4-2/h6-8,10,13-14,26H,3-5,9,11-12H2,1-2H3
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Amiodarone N-deethylation in human liver microsomes: involvement of cytochrome P450 3A enzymes (first report). | 1993 |
|
| Desethylamiodarone is a noncompetitive inhibitor of the binding of thyroid hormone to the thyroid hormone beta 1-receptor protein. | 1994 Apr |
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| Desethylamiodarone is a competitive inhibitor of the binding of thyroid hormone to the thyroid hormone alpha 1-receptor protein. | 1995 Jul |
|
| Effects of triiodothyronine and amiodarone on the promoter of the human LDL receptor gene. | 1998 Aug 19 |
|
| Desethylamiodarone antagonizes the effect of thyroid hormone at the molecular level. | 2001 Jul |
|
| Dronerarone acts as a selective inhibitor of 3,5,3'-triiodothyronine binding to thyroid hormone receptor-alpha1: in vitro and in vivo evidence. | 2003 Feb |
|
| Amiodarone and N-desethylamiodarone enhance endothelial nitric oxide production in human endothelial cells. | 2006 Jan |
|
| Amiodarone analog-dependent effects on CYP2C9-mediated metabolism and kinetic profiles. | 2006 Oct |
|
| Stimulation of human monocytic THP-1 cells by metabolic activation of hepatotoxic drugs. | 2012 |
|
| Cytotoxic interaction between amiodarone and desethylamiodarone in human peripheral lung epithelial cells. | 2013 Aug 25 |
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C036116
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DTXSID00232344
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83409-32-9
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1027346
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M31FU99E3Y
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104774
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PARENT (METABOLITE ACTIVE)
SUBSTANCE RECORD
